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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 61 - 72 (12page)
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Chios gum mastic (CGM) is a resin produced from thestem and leaves of Pistiacia lentiscus L var chia, a plantwhich grows only on Chios Island in Greece. CGM has beenused for many centuries as a dietary supplement and folkmedicine for stomach and duodenal ulcers in manyMediterranean countries and is known also to induce cellcycle arrest and apoptosis in some cancer cells. In this study,we further investigated the induction and mechanismsunderlying the apoptotic response to CGM treatment in theSCC25 human tongue squamous cell carcinoma cell line.
The viability of SCC25 cells, human normal keratinocytes(HaCaT cells) and human gingival fibroblasts (HGF-1cells), and the growth inhibition of SCC25 cells wereassessed by MTT assay and clonogenic assay, respectively.
Staining with Hoechst and hemacolor dyes and TUNELassays were employed to detect SCC25 cells undergoingapoptosis. SCC25 cells were treated with CGM, and thiswas followed by western blotting, immunocytochemistry,confocal microscopy, FACScan flow cytometry, MMPactivity and proteasome activity analyses. CGM treatmentof SCC25 cells was found to result in a time- and dosedependentdecrease in cell viability, a dose-dependentinhibition of cell growth, and apoptotic cell death. Interestingly,CGM showed a remarkable level of cytotoxicity inSCC25 cells but not in normal cells. Tested SCC25 cells alsoshowed several lines of apoptotic manifestation. Takentogether, our present findings demonstrate that CGM stronglyinhibits cell proliferation by modulating the expression of G1cell cycle-related proteins and induces apoptosis via theproteasome, mitochondria and caspase cascades in SCC25 cells.
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참고문헌 (25)
참고문헌 신청
Acehan D / 2002 / Three-dimensional structure of the apoptosome: Impli cations for assembly, procaspase-9 binding, and activation / Mol Cell 9 : 423 ~ 432
Aksoy A / 2006 / In vitro and in vivo antimicrobial effects of mastic chewing gum against Streptococcus mutans and mutans streptococci / Arch Oral Biol 51 : 476 ~ 481
Al-Habbal MJ / 1984 / A double-blind controlled clinical trial of mastic and placebo in the treatment of duodenal ulcer / Clin Exp Pharmacol Physiol 11 : 541 ~ 544
Al-Said MS / 1986 / Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti-ulcer activity / J Ethnopharmacol 15 : 271 ~ 278
Balan KV / 2007 / Antiproliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lent
Aksoy A / 2006 / In vitro and in vivo antimicrobial effects of mastic chewing gum against Streptococcus mutans and mutans streptococci / Arch Oral Biol 51 : 476 ~ 481
Al-Habbal MJ / 1984 / A double-blind controlled clinical trial of mastic and placebo in the treatment of duodenal ulcer / Clin Exp Pharmacol Physiol 11 : 541 ~ 544
Al-Said MS / 1986 / Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti-ulcer activity / J Ethnopharmacol 15 : 271 ~ 278
Balan KV / 2007 / Antiproliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lent
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