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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 123 - 128 (6page)
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초록· 키워드
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Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder for which no curative treatment is available.
We previously reported that decreased Streptococcus salivarius and increased Acinetobacter johnsonii on the oral mucosa are associated with RAS risk. The purpose of this study was to identify antibiotics that selectively inhibit A.
johnsonii but minimally inhibit oral mucosal commensals. S.
salivarius KCTC 5512, S. salivarius KCTC 3960, A. johnsonii KCTC 12405, Rothia mucilaginosa KCTC 19862, and Veillonella dispar KCOM 1864 were subjected to antibiotic susceptibility test using amoxicillin, cefotaxime, gentamicin, clindamycin, and metronidazole in liquid culture. The minimal inhibitory concentration (MIC) was defined as the concentration that inhibits 90% of growth. Only gentamicin presented a higher MIC for A. johnsonii than MICs for S.
salivarius and several oral mucosal commensals. Interestingly, the growth of S. salivarius increased 10~200% in the presence of sub-MIC concentrations of gentamicin, which was independent of development of resistance to gentamicin. In conclusion, gentamicin may be useful to restore RASassociated imbalance in oral microbiota by selectively inhibiting the growth of A. johnsonii but enhancing the growth of S. salivarius.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Andrews JM / 2001 / Determination of minimum inhibitory concentrations / J Antimicrob Chemother 48 (Suppl 1) : 5 ~ 16
Cerith Jones / 2013 / Subinhibitory Concentration of Kanamycin Induces the Pseudomonas aeruginosa type VI Secretion System / PLoS ONE 8 (11) : e81132 ~
Charisse Petersen / 2014 / Defining dysbiosis and its influence on host immunity and disease / Cellular Microbiology 16 (7) : 1024 ~ 1033
Crispian Scully / 2006 / Aphthous Ulceration / New England Journal of Medicine 355 (2) : 165 ~ 172
Crispian Scully / 2008 / Oral mucosal disease: Recurrent aphthous stomatitis / British Journal of Oral and Maxillofacial Surgery 46 (3) : 198 ~ 206
Cerith Jones / 2013 / Subinhibitory Concentration of Kanamycin Induces the Pseudomonas aeruginosa type VI Secretion System / PLoS ONE 8 (11) : e81132 ~
Charisse Petersen / 2014 / Defining dysbiosis and its influence on host immunity and disease / Cellular Microbiology 16 (7) : 1024 ~ 1033
Crispian Scully / 2006 / Aphthous Ulceration / New England Journal of Medicine 355 (2) : 165 ~ 172
Crispian Scully / 2008 / Oral mucosal disease: Recurrent aphthous stomatitis / British Journal of Oral and Maxillofacial Surgery 46 (3) : 198 ~ 206
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