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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 49 - 54 (6page)
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AbstractObjective: Antibiotic resistance is a global health problem and threatens health of societies. These problems have led to a search for alternative approaches such as combination therapy. The aim of the present study was to investigate the effect of caffeine and omeprazole in combination with gentamicin or ciprofloxacin against standard and clinically resistant isolates of Staphylococcus aureus and Escherichia coli. Methods: The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of different agents against bacterial strains were determined. The interaction of non- antibiotic drugs with gentamicin and ciprofloxacin was studied in vitro using a checkerboard method and calculating fraction inhibitory concentration index (FICI). Verapamil as ef-flux pump inhibitor was used to evaluate the possible mechanism of bacterial resistance to antibiotics. Results: The MIC and MBC values of gentamicin against bacterial strains were in the range of 20- 80 μg/ml and 40-200 μg/ml, respectively. Caffeine and omeprazole had no intrinsic inhibitory activity against tested microorganisms. However, upon combination of caffeine with antibiotics, the synergistic effects were observed. Verapamil was able to reduce the MIC values of gentamicin (4 folds) only in some bacterial strains. Conclusion: These findings indicated that caffeine was effective in removing bacterial infection caused by S. aureus and E. coli. The relevant mechanisms of antibiotic resistance were not related to the drug efflux.
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참고문헌 (27)
참고문헌 신청
Khameneh B / 2016 / Breakthroughs in bacterial resistance mechanisms and the potential ways to combat them / Microb Pathog 95:32~42
Khademi F / 2015 / Helicobacter pylori in Iran : A systematic review on the antibiotic resistance / Iran J Basic Med Sci 18:2~7
Fazly Bazzaz BS / 2018 / In vitro evaluation of antibacterial activity of verbascoside, lemon verbena extract and caffeine in combination with gentamicin against drug-resistant Staphylococcus aureus and Escherichia coli clinical isolates / Avicenna J Phytomed 8:246~253
Pantosti A / 2007 / Mechanisms of antibiotic resistance in Staphylococcus aureus / Future Microbiol 2:323~334
Corvec S / 2013 / Activities of fosfomycin, tigecycline, colistin, and gentamicin against extended-spectrum-lactamase-producing Escherichia coli in a foreign-body infection model / Antimicrob Agents Chemother 57:1421~1427
Khademi F / 2015 / Helicobacter pylori in Iran : A systematic review on the antibiotic resistance / Iran J Basic Med Sci 18:2~7
Fazly Bazzaz BS / 2018 / In vitro evaluation of antibacterial activity of verbascoside, lemon verbena extract and caffeine in combination with gentamicin against drug-resistant Staphylococcus aureus and Escherichia coli clinical isolates / Avicenna J Phytomed 8:246~253
Pantosti A / 2007 / Mechanisms of antibiotic resistance in Staphylococcus aureus / Future Microbiol 2:323~334
Corvec S / 2013 / Activities of fosfomycin, tigecycline, colistin, and gentamicin against extended-spectrum-lactamase-producing Escherichia coli in a foreign-body infection model / Antimicrob Agents Chemother 57:1421~1427
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