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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 91 - 97 (7page)
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초록· 키워드
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Although anti-aging activities of melatonin, a hormone secreted by the pineal gland, have been reported in senescence-accelerated mouse models and several types of cells, its impact and mechanism on the senescence of human dental pulp cells (HDPCs) remains unknown. In this study, we examined the impact of melatonin on cellular premature senescence of HDPCs. Here, we found that melatonin markedly inhibited senescent characteristics of HDPCs after exposure to hydrogen peroxide (H2O2), including the increase in senescence-associated β-galactosidase (SA-β -gal)-positive HDPCs and the upregulation of p21 protein, an indicator for senescence. In addition, as melatonin attenuated H2O2-stimulated phosphorylation of c-Jun N-terminal kinase (JNK), while selective inhibition of JNK activity with SP600125 significantly attenuated H2O2-induced increase in SA-beta-gal activity. Results reveal that melatonin antagonizes premature senescence of HDPCs via JNK pathway. Thus, melatonin may have therapeutic potential to prevent stress-induced premature senescence, possibly correlated with development of dental pulp diseases, and to maintain oral health across the life span.
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참고문헌 (33)
참고문헌 신청
Beatriz Caballero / 2009 / Melatonin alters cell death processes in response to age-related oxidative stress in the brain of senescence-accelerated mice / Journal of Pineal Research 46(1):106~114
Henry Jay Forman / 2016 / Redox signaling: An evolution from free radicals to aging / Free Radical Biology and Medicine 97:398~407
Seomun Y / 2005 / Induction of p21Cip1-mediated G2/M arrest in H2O2-treated lens epithelial cells / Mol Vis 11:764~774
Wang X / 1998 / The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival / Biochem J 333(Pt 2):291~300
Ester Martínez-Sarrà / 2017 / Human dental pulp pluripotent-like stem cells promote wound healing and muscle regeneration / Stem Cell Research & Therapy 8(1):175
Henry Jay Forman / 2016 / Redox signaling: An evolution from free radicals to aging / Free Radical Biology and Medicine 97:398~407
Seomun Y / 2005 / Induction of p21Cip1-mediated G2/M arrest in H2O2-treated lens epithelial cells / Mol Vis 11:764~774
Wang X / 1998 / The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival / Biochem J 333(Pt 2):291~300
Ester Martínez-Sarrà / 2017 / Human dental pulp pluripotent-like stem cells promote wound healing and muscle regeneration / Stem Cell Research & Therapy 8(1):175
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