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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 194 - 201 (8page)
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초록· 키워드
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Background: Flecainide is an antiarrhythmic agent that is used primarily in the treatment of cardiac arrhythmias. Some evidences also suggest that flecainide can participate in alveolar fluid clearance and inflammatory responses. This experiment was aimed to evaluate the effects of flecainide on sepsis induced acute lung injury in a rat model.
Methods: Rats were treated with subcutaneous infusion of saline or flecainide (0.1 or 0.2 mg/kg/hr) by a mini-osmotic pump. Subcutaneous infusion was started 3 hours before and continued until 8 hours after intraperitoneal injection of saline or endotoxin. Animals were sacrificed for analyses of severity of acute lung injury with wet to dry (W/D) ratio and lung injury score (LIS) in lung and inflammatory responses with level of leukocyte, polymorphonuclear neutrophils (PMNs) and inteleukin-8 (IL-8) in bronchoalveolar lavages fluid (BALF).
Results: Flecainide markedly improved dose dependently sepsis induced acute lung injury as analysed by W/D ratio (from 2.24 ± 0.11 to 1.76 ± 0.09, p < 0.05) and LIS (from 3 to 1, p < 0.05), and inflammatory response as determined by leukocyte (from 443 ± 127 to 229 ± 95, p < 0.05), PMNs (from 41.43 ± 17.63 to 2.43 ± 2.61, p < 0.05) and IL-8 (from 95.00 ± 15.28 to 40.00 ± 10.21, p < 0.05) in BALF.
Conclusions: Flecanide improve sepsis induced acute lung injury in rats by controlling inflammatory responses.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Held HD / 2000 / Mechanisms of endotoxin-induced airway and pulmonary vascular hyperreactivity in mice / Am J Respir Crit Care Med 162(4Pt 1):1547~1552
Kosari F / 1998 / Subunit stoichiometry of the epithelial sodium channel / J Biol Chem 273:13469~13474
Samlowski WE / 1987 / Flecainideinduced immune neutropenia. Documentation of a hapten-mediated mechanism of cell destruction / Arch Intern Med 147:383~384
Kwak SH / 2005 / The kringle domain of urokinase-type plasminogen activator potentiates LPS-induced neutrophil activation through interaction with {alpha}V{beta}3 integrins / J Leukoc Biol 78:937~945
Abraham E / 2000 / HMG-1 as a mediator of acute lung inflammation / J Immunol 165:2950~2954
Kosari F / 1998 / Subunit stoichiometry of the epithelial sodium channel / J Biol Chem 273:13469~13474
Samlowski WE / 1987 / Flecainideinduced immune neutropenia. Documentation of a hapten-mediated mechanism of cell destruction / Arch Intern Med 147:383~384
Kwak SH / 2005 / The kringle domain of urokinase-type plasminogen activator potentiates LPS-induced neutrophil activation through interaction with {alpha}V{beta}3 integrins / J Leukoc Biol 78:937~945
Abraham E / 2000 / HMG-1 as a mediator of acute lung inflammation / J Immunol 165:2950~2954
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