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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 526 - 530 (5page)
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초록· 키워드
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Human epididymis protein 4 (HE4) has been suggested as a useful new biomarker of lung cancer; however, few relevant large-scale studies have been published. In this study, we evaluated the utility of serum HE4 for lung cancer detection. HE4 levels were measured in serum samples from 100 lung cancer patients, 57 patients with benign lung diseases, and 274 healthy controls by using a chemiluminescent immunoassay, and variations in HE4 levels were analyzed by clinical status such as lung cancer, benign lung disease, and healthy condition, Tumor, Lymph Nodes, Metastasis (TNM) stage, tumor score, and histological cancer type. Lung cancer patients had significantly higher serum HE4 levels than patients with benign lung diseases and healthy controls (P<0.0001). The area under the ROC curve for HE4 was 0.84 (95% confidence interval, 0.78–0.89; P<0.0001) between lung cancer patients and healthy controls. Serum HE4 levels were significantly higher in patients with advanced disease (according to TNM stage) than in healthy controls (P<0.0001). HE4 levels were significantly elevated in patients with tumors of all types, those of different histological subgroups, and those with the smallest tumors (P= 0.002). This report supports the potential of serum HE4 as an ancillary diagnostic marker for lung cancer detection,
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참고문헌 (19)
참고문헌 신청
Brower V / 2009 / Biomarker studies abound for early detection of lung cancer / J Natl Cancer Inst 101 : 11 ~ 13
Devoogdt N / 2004 / Secretory leukocyte protease inhibitor in cancer development / Ann N Y Acad Sci 1028 : 380 ~ 389
Escudero JM / 2011 / Comparison of serum human epididymis protein 4 with cancer antigen 125 as a tumor marker in patients with malignant and nonmalignant diseases / Clin Che
Ferraro S / 2013 / Serum human epididymis protein 4 vs carbohydrate antigen 125 for ovarian cancer diagnosis: a systematic review / J Clin Pathol 66 : 273 ~ 281
Galateau-Salle F / 2016 / The 2015 World Health Organization classification of tumors of the pleura: Advances since the 2004 classification / J Thorac Oncol 11 : 142 ~ 154
Devoogdt N / 2004 / Secretory leukocyte protease inhibitor in cancer development / Ann N Y Acad Sci 1028 : 380 ~ 389
Escudero JM / 2011 / Comparison of serum human epididymis protein 4 with cancer antigen 125 as a tumor marker in patients with malignant and nonmalignant diseases / Clin Che
Ferraro S / 2013 / Serum human epididymis protein 4 vs carbohydrate antigen 125 for ovarian cancer diagnosis: a systematic review / J Clin Pathol 66 : 273 ~ 281
Galateau-Salle F / 2016 / The 2015 World Health Organization classification of tumors of the pleura: Advances since the 2004 classification / J Thorac Oncol 11 : 142 ~ 154
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