지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 333 - 339 (7page)
이용수
초록· 키워드
오류제보하기
Background: Severe or massive postpartum hemorrhage (PPH) has remained a leading cause of maternal mortality for decades across the world and it results in critical obstetric complications. Recombinant activated factor VII (rFVIIa) has emerged as a gold standard adjunctive hemostatic agent for the treatment of life-threatening PPH refractory to conventional therapies although it remains off-licensed for use in PPH. We studied the effects of rFVIIa on coagulopathy, transfusion volume, prognosis, severity change in Korean PPH patients.
Methods: A retrospective review of medical records between December 2008 and March 2011 indicating use of rFVIIa in severe PPH was performed. We compared age, rFVIIa treatment, transfusion volume, and Sequential Organ Failure Assessment (SOFA) score at the time of arrival in the emergency department and after 24 hours for patients whose SOFA score was 8 points or higher.
Results: Fifteen women with SOFA score of 8 and above participated in this study and eight received rFVIIa administration whereas seven did not. Patients’ mean age was 31.7 ± 7.5 years. There was no statistically significant difference in initial and post-24 hours SOFA scores between patients administered rFVIIa or not. The change in SOFA score between initial presentation and after 24 hours was significantly reduced after rFVIIa administration (P = 0.016).
Conclusions: This analysis aimed to support that the administration of rFVIIa can reduce the severity of life-threatening PPH in patients.
A rapid decision regarding the administration of rFVIIa is needed for a more favorable outcome in severe PPH patients for whom there is no effective standard treatment.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Aledort LM. / 2004 / Comparative thrombotic event incidence after infusion of recombinant factor VIIa versus factor VIII inhibitor bypass activity / J Thromb Haemost 2 : 170
Alfirevic Z / 2007 / Use of recombinant activated factor VII in primary postpartum hemorrhage:the Northern European registry 2000-2004 / Obstet Gynecol 110 : 1270 ~ 1278
Biss TT / 2006 / Recombinant activated factor VII (rFVIIa/NovoSeven) in intractable haemorrhage:use of a clinical scoring system to predict outcome / Vox Sang 90 : 45 ~ 52
Bomken C / 2009 / Recombinant activated factor VII (rFVIIa) in the management of major obstetric haemorrhage: a case series and a proposed guideline for use / Obstet Gynecol
Ferreira FL / 2001 / Serial evaluation of the SOFA score to predict outcome in critically ill patients / JAMA 286 : 1754 ~ 1758
Alfirevic Z / 2007 / Use of recombinant activated factor VII in primary postpartum hemorrhage:the Northern European registry 2000-2004 / Obstet Gynecol 110 : 1270 ~ 1278
Biss TT / 2006 / Recombinant activated factor VII (rFVIIa/NovoSeven) in intractable haemorrhage:use of a clinical scoring system to predict outcome / Vox Sang 90 : 45 ~ 52
Bomken C / 2009 / Recombinant activated factor VII (rFVIIa) in the management of major obstetric haemorrhage: a case series and a proposed guideline for use / Obstet Gynecol
Ferreira FL / 2001 / Serial evaluation of the SOFA score to predict outcome in critically ill patients / JAMA 286 : 1754 ~ 1758
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