지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Bisphosphonates reduce bone loss by suppressing osteoclast activity and are currently used for the treatment of osteoporosis. As a side effect of bisphosphonates treatment, the emergence of osteonecrosis of the jaw (ONJ) has stimulated interest in elucidating how bisphosphonates affect the bone, but far less understanding exists as to the ONJ mechanism. In the present study, it was hypothesized that bisphosphonates may affect the healing of the alveolar socket by altering VEFG regulation. In vivo osteoporosis rat models were made by bilateral surgical ovariectomy. Pamidronate (3.5 mg/kg/wk) was IP injected for 8 wks and the maxillary 1st molars were bilaterally extracted. For in vitro test, periodontal ligament cells were treated with pamidronate. Unexpectedly, VEFG-A and -B mRNA and protein levels were increased in in vivo and in vitro by the high concentration treatment of bisphosphonates. However, VEGF-C level was not changed. In the socket at day 7 after the molar extraction, the socket was filled with infiltration of neutrophils which showed strong immunoreactivity against VEGF. VEGF-B mRNA was in particular upregulated by the pamidronate treatment. This result suggest that high dose pamidronate may alter VEGF expression that may serve as another mechanism of ONJ.
목차
등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
American Dental Association Council on Scientific Affairs / 2006 / Dental management of patients receiving oral bisphosphonate therapy / J Am Dent Assoc 137:1144~1150
Drake M / 2011 / Bisphosphonates:Mechanism of action and role in clinical practice / Mayo Clin Proc 83:1032~1045
George EL / 2018 / Bisphosphonate-related osteonecrosis of the jaw: a mechanobiology perspective / Bone Rep 15(8):104~109
Heron P / 2018 / Bisphosphonate inhibitors of mammalian glycolytic aldolase / J Med Chem
Cartsos VM / 2008 / Bisphosphonate use and the risk of adverse jaw outcomes: A medical claims study of 714,217 people / J Am Dent Assoc 139:23~30
Drake M / 2011 / Bisphosphonates:Mechanism of action and role in clinical practice / Mayo Clin Proc 83:1032~1045
George EL / 2018 / Bisphosphonate-related osteonecrosis of the jaw: a mechanobiology perspective / Bone Rep 15(8):104~109
Heron P / 2018 / Bisphosphonate inhibitors of mammalian glycolytic aldolase / J Med Chem
Cartsos VM / 2008 / Bisphosphonate use and the risk of adverse jaw outcomes: A medical claims study of 714,217 people / J Am Dent Assoc 139:23~30
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Effects of Low-Dose Bisphosphonate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Patients With Osteoporosis
Annals of geriatric medicine and research
2016 .01
-
Efficacy and safety of intravenous pamidronate infusion for treating osteoporosis in children and adolescents
Annals of Pediatirc Endocrinology & Metabolism
2021 .01
-
Medication Related Osteonecrosis of the Jaw: 2015 Position Statement of the Korean Society for Bone and Mineral Research and the Korean Association of Oral and Maxillofacial Surgeons
대한골대사학회지
2015 .01
-
골다공증 치료 약제와 턱뼈괴사증의 이해
대한치과의사협회지
2021 .10
-
Effectiveness and safety of pamidronate treatment in nonambulatory children with low bone mineral density
Annals of Pediatirc Endocrinology & Metabolism
2024 .02
-
Bisphosphonate Use Does Not Impact Survival in Patients with Pancreatic Cancer: A Propensity Score Matching Analysis
Gut and Liver
2021 .09
-
Physicians’ Attitudes on Management of Osteopenia in South Korea
대한골대사학회지
2020 .01
-
Diseases having an influence on inhibition of angiogenesis as risk factors of osteonecrosis of the jaw
대한구강악안면외과학회지
2016 .01
-
The impact of sex steroids on osteonecrosis of the jaw
Osteoporosis and Sarcopenia
2022 .06
-
Bisphosphonate-related osteonecrosis of the jaw in a multiple myeloma patient: A case report with characteristic radiographic features
Imaging science in dentistry
2015 .01
-
The Frequency of and Risk Factors for the Use of Bisphosphonates in the Adjuvant Setting of Primary Breast Cancer in Germany
Cancer Research and Treatment
2015 .01
-
Bisphosphonate-Related Osteonecrosis in a Patient with Florid Cemento-Osseous Dysplasia
Journal of Oral Medicine and Pain
2021 .06
-
A rare case of osteonecrosis of the jaw related to imatinib
대한구강악안면외과학회지
2017 .01
-
Can Alarming Improve Compliance with Weekly Bisphosphonate in Patients with Osteoporosis?
대한골대사학회지
2016 .01
-
Efficacy of pamidronate in pediatric osteosarcoma patients with low bone mineral density
Annals of Pediatirc Endocrinology & Metabolism
2016 .01
-
A case of bisphosphonate-related osteonecrosis of the jaw with a particularly unfavourable course: a case report
대한구강악안면외과학회지
2017 .08
-
Bisphosphonate-related osteonecrosis of the jaw in patients received long term treatment of oral bisphosphonate administration: Case reports
Oral Biology Research
2016 .01
-
Medication Related Osteonecrosis of the Jaw: 2021 Position Statement of the Korean Society for Bone and Mineral Research and the Korean Association of Oral and Maxillofacial Surgeons
대한골대사학회지
2021 .11
-
Which Bisphosphonate? It’s the Compliance!: Decision Analysis
대한골대사학회지
2016 .01
-
Bisphosphonate-related osteonecrosis of the jaw in a patient with osteoporosis following treatment of testicular cancer: a case report
대한구강악안면외과학회지
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0