지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: The best options of several bisphosphonates for prevention of osteoporotic fractures in postmenopausal women remain controversial. We determined which bisphosphonate provides better efficacy in prevention of osteoporotic fractures using a decision analysis tool, in terms of quality of life. Methods: A decision analysis model was constructed containing final outcome score and the probability of vertebral and hip fracture within 1 year. Final outcome was defined as health-related quality of life, and was used as an utility in the decision tree. Probabilities were obtained by literature review, and health-related quality of life was evaluated by consensus committee. A roll back tool was used to determine the best bisphosphonate, and sensitivity analysis was performed to compensate for decision model uncertainty. Results: The decision model favored bisphosphonate with higher compliance in terms of quality of life. In one-way sensitivity analysis, ibandronate was more beneficial than the others, when probability of compliance on ibandronate was above 0.589. Conclusions: In terms of quality of life, the decision analysis model showed that compliance was most important for patients in real world, regardless of type of bisphosphonate.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Black DM / 1996 / Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group / Lancet 348:1535~1541
Harris ST / 1999 / Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group / JAMA 282:1344~1352
Chesnut CH 3rd / 2004 / Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis / J Bone Miner Res 19:1241~1249
Black DM / 2007 / Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis / N Engl J Med 356:1809~1822
Brauer CA / 2009 / Using observational data for decision analysis and economic analysis / J Bone Joint Surg Am 91(Suppl 3):73~79
Harris ST / 1999 / Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group / JAMA 282:1344~1352
Chesnut CH 3rd / 2004 / Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis / J Bone Miner Res 19:1241~1249
Black DM / 2007 / Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis / N Engl J Med 356:1809~1822
Brauer CA / 2009 / Using observational data for decision analysis and economic analysis / J Bone Joint Surg Am 91(Suppl 3):73~79
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