지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background/Aims : Disruption of the cell-to-cell junction with changes in the expression of the junctional proteins is the hallmark of cancer invasion and metastasis. To investigate the roles of claudin-1, β-catenin and E-cadherin in adenocarcinoma of the colon, the relationship of their expression with clinical and pathological factors were examined.
Methods : The expression of claudin-1, β-catenin and E-cadherin were examined in 47 cases of adenocarcinoma of the colon by immunohistochemical staining.
Results : A reduced claudin-1 expression was associated with advanced lymph node metastasis (p=0.019) and histological dedifferentiation at the invasive front (p=0.030). A reduced expression of β-catenin and E-cadherin were correlated with histological dedifferentiation (p=0.012, p=0.010, respectively). The reduced expression of two or more proteins was correlated with the histological findings of dedifferentiation (p=0.030).
Conclusions : These results suggest that loss of claudin-1, β-catenin and E-cadherin expression may be correlated with the progression of adenocarcinoma of the colon and associated with an advanced histological grade. (Korean J Med 74:146-153, 2008)
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참고문헌 (22)
참고문헌 신청
Chakrabarty S / 2003 / Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-cate
Cohn ML / 2005 / Loss of claudin-1 expression in tumor-associated vessels correlates with acquisition of metastatic phenotype in melanocytic neoplasms / J Cutan Pathol 32
Dhawan P / 2005 / Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer / J Clin Invest 115 : 1765 ~ 1776
Furuse M / 2002 / Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice / J Cell Biol 156 : 1099 ~ 1111
Gofuku J / 1999 / Expression of E-cadherin and alpha-catenin in patients with colorectal carcinoma: correlation with cancer invasion and metastasis / Am J Clin Pathol 111 :
Cohn ML / 2005 / Loss of claudin-1 expression in tumor-associated vessels correlates with acquisition of metastatic phenotype in melanocytic neoplasms / J Cutan Pathol 32
Dhawan P / 2005 / Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer / J Clin Invest 115 : 1765 ~ 1776
Furuse M / 2002 / Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice / J Cell Biol 156 : 1099 ~ 1111
Gofuku J / 1999 / Expression of E-cadherin and alpha-catenin in patients with colorectal carcinoma: correlation with cancer invasion and metastasis / Am J Clin Pathol 111 :
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