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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Philadelphia chromosome-positive acute myeloid leukemia (Ph+AML) is a rare disease characterized by a poor prognosis with resistance to standard chemotherapy. We report a patient with Ph+AML with a minor BCR-ABL-positive mRNA transcript who achieved a hematologic, cytogenetic, and major molecular complete response after cytarabine-based chemotherapy followed by imatinib. After more than 6 months of continuous imatinib therapy, the patient is in continuous complete remission. Our results show that imatinib mesylate is effective in treating Ph+AML.
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참고문헌 (16)
참고문헌 신청
Advani AS / 2004 / Philadelphia chromosome positive myelodysplastic syndrome and acute myeloid leukemia / Leuk Res 28 : 545 ~ 546
Altman AJ / 1990 / Clinical features and biological implications of acute mixed lineage (hybrid) leukemias / Am J Pediatr Hematol Oncol 12 : 123 ~ 133
Berger R / 1993 / Differences between blastic chronic myeloid leukemia and Ph-positive acute leukemia / Leuk Lymphoma 11 (Suppl 1) : 235 ~ 237
Druker BJ / 1996 / Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells / Nat Med 2 : 561 ~ 566
Druker BJ / 2001 / Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the P
Altman AJ / 1990 / Clinical features and biological implications of acute mixed lineage (hybrid) leukemias / Am J Pediatr Hematol Oncol 12 : 123 ~ 133
Berger R / 1993 / Differences between blastic chronic myeloid leukemia and Ph-positive acute leukemia / Leuk Lymphoma 11 (Suppl 1) : 235 ~ 237
Druker BJ / 1996 / Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells / Nat Med 2 : 561 ~ 566
Druker BJ / 2001 / Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the P
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