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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제51권 제3호
- 발행연도
- 2017.1
- 수록면
- 191 - 204 (14page)
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초록· 키워드
오류제보하기
Next-generation sequencing (NGS) has recently emerged as an essential component of personalized cancer medicine due to its high throughput and low per-base cost. However, no sufficient guidelines for implementing NGS as a clinical molecular pathology test are established in Korea. To ensure clinical grade quality without inhibiting adoption of NGS, a taskforce team assembled by the Korean Society of Pathologists developed laboratory guidelines for NGS cancer panel testing procedures and requirements for clinical implementation of NGS. This consensus standard proposal consists of two parts: laboratory guidelines and requirements for clinical NGS laboratories. The laboratory guidelines part addressed several important issues across multistep NGS cancer panel tests including choice of gene panel and platform, sample handling, nucleic acid management, sample identity tracking, library preparation, sequencing, analysis and reporting. Requirements for clinical NGS tests were summarized in terms of documentation, validation, quality management, and other required written policies. Together with appropriate pathologist training and international laboratory standards, these laboratory standards would help molecular pathology laboratories to successfully implement NGS cancer panel tests in clinic. In this way, the oncology community would be able to help patients to benefit more from personalized cancer medicine.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
[학술지(정기간
Aziz N / 2015 / College of American Pathologists' laboratory standards for next-generation sequencing clinical tests / Arch Pathol Lab Med 139 : 481 ~ 493
Bentley DR / 2008 / Accurate whole human genome sequencing using reversible terminator chemistry / Nature 456 : 53 ~ 59
Brownstein CA / 2014 / An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing result
Burghel GJ / 2015 / Towards a next-generation sequencing diagnostic service for tumour genotyping: a comparison of panels and platforms / Biomed Res Int 2015 : 478017 ~
Aziz N / 2015 / College of American Pathologists' laboratory standards for next-generation sequencing clinical tests / Arch Pathol Lab Med 139 : 481 ~ 493
Bentley DR / 2008 / Accurate whole human genome sequencing using reversible terminator chemistry / Nature 456 : 53 ~ 59
Brownstein CA / 2014 / An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing result
Burghel GJ / 2015 / Towards a next-generation sequencing diagnostic service for tumour genotyping: a comparison of panels and platforms / Biomed Res Int 2015 : 478017 ~
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