지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 914 - 923 (10page)
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초록· 키워드
오류제보하기
Purpose: Few efforts have been made to integrate a next generation sequencing (NGS) panel into standard clinical treatment ofovarian cancer. The aim of this study was to investigate the clinical utility of NGS and to identify clinically impactful informationbeyond targetable alterations. Materials and Methods: We conducted a retrospective review of 84 patients with ovarian cancer who underwent NGS betweenMarch 1, 2017, and July 31, 2018, at the Yonsei Cancer Hospital. We extracted DNA from formalin-fixed, paraffin-embedded tissuesamples of ovarian cancer. The TruSight Tumor 170 gene panel was used to prepare libraries, and the MiSeq instrument wasused for NGS. Results: Of the 84 patients, 55 (65.1%) had high-grade serous carcinomas. Seventy-three (86.7%) patients underwent NGS at the timeof diagnosis, and 11 (13.3%) underwent NGS upon relapse. The most common genetic alterations were in TP53 (64%), PIK3CA (15%),and BRCA1/2 (13%), arising as single nucleotide variants and indels. MYC amplification (27%) was the most common copy numbervariation and fusion. Fifty-seven (67.9%) patients had more than one actionable alteration other than TP53. Seven (8.3%) casesreceived matched-target therapy based on the following sequencing results: BRCA1 or 2 mutation, poly ADP ribose polymeraseinhibitor (n=5); PIK3CA mutation, AKT inhibitor (n=1); and MLH1 mutation, PD-1 inhibitor (n=1). Fifty-three (63.0%) patients hada possibility of treatment change, and 8 (9.5%) patients received genetic counseling. Conclusion: Implementation of NGS may help in identifying patients who might benefit from targeted treatment therapies andgenetic counseling.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
이정윤 / 2014 / Trends in gynecologic cancer mortality in East Asian regions / Journal of Gynecologic Oncology 25(3):174~182
임명철 / 2013 / Incidence of cervical, endometrial, and ovarian cancer in Korea, 1999-2010 / Journal of Gynecologic Oncology 24(4):298~302
Winter WE 3rd / 2007 / Prognostic factors for stage III epithelial ovarian cancer : a Gynecologic Oncology Group Study / J Clin Oncol 25:3621~3627
Groisberg R / 2018 / Clinical next-generation sequencing for precision oncology in rare cancers / Mol Cancer Ther 17:1595~1601
Carr TH / 2016 / Defining actionable mutations for oncology therapeutic development / Nat Rev Cancer 16:319~329
임명철 / 2013 / Incidence of cervical, endometrial, and ovarian cancer in Korea, 1999-2010 / Journal of Gynecologic Oncology 24(4):298~302
Winter WE 3rd / 2007 / Prognostic factors for stage III epithelial ovarian cancer : a Gynecologic Oncology Group Study / J Clin Oncol 25:3621~3627
Groisberg R / 2018 / Clinical next-generation sequencing for precision oncology in rare cancers / Mol Cancer Ther 17:1595~1601
Carr TH / 2016 / Defining actionable mutations for oncology therapeutic development / Nat Rev Cancer 16:319~329
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