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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제52권 제2호
- 발행연도
- 2018.1
- 수록면
- 121 - 125 (5page)
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초록· 키워드
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Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-year-old woman. A radical cholecystectomy specimen revealed a 4.3 × 4.0 cm polypoid mass in the fundus with infiltration of adjacent liver parenchyma. Microscopically, the tumor consisted of two distinct components. Adenosquamous carcinoma was predominant and abrupt transition from adenocarcinoma to squamous cell carcinoma was observed. LCNEC showed round cells with large, vesicular nuclei, abundant mitotic figures, and occasional pseudorosette formation. The patient received adjuvant chemotherapy. However, multiple liver metastases were identified at 3-month follow-up. Metastatic nodules were composed of LCNEC and squamous cell carcinoma components. Detecting LCNEC component is important in gallbladder cancer, because the tumor may require a different chemotherapy regimen and show early metastasis and poor prognosis.
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
National Cancer Institute / 2008 / SEER data, 1973-2005 [Internet]
Henson DE / 1992 / Carcinoma of the gallbladder: histologic types, stage of disease, grade, and survival rates / Cancer 70:1493~1497
Liu W / 2015 / Mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: a case report and brief review of the literature / World J Surg Oncol 13:114
Buscemi S / 2016 / "Pure" large cell neuroendocrine carcinoma of the gallbladder: report of a case and review of the literature / Int J Surg 28(Suppl 1):S128~S132
Eltawil KM / 2010 / Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy / J Clin Gastroenterol 44:687~695
Henson DE / 1992 / Carcinoma of the gallbladder: histologic types, stage of disease, grade, and survival rates / Cancer 70:1493~1497
Liu W / 2015 / Mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: a case report and brief review of the literature / World J Surg Oncol 13:114
Buscemi S / 2016 / "Pure" large cell neuroendocrine carcinoma of the gallbladder: report of a case and review of the literature / Int J Surg 28(Suppl 1):S128~S132
Eltawil KM / 2010 / Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy / J Clin Gastroenterol 44:687~695
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