Multiregion Comprehensive Genomic Profiling of a Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm with Trilineage Differentiation

Faheem Farooq; Kevin Zarrabi; Keith Sweeney; 김요셉; Jela Bandovic; Chiraag Patel; 최민식

doi:https://doi.org/10.5230/jgc.2018.18.e16

추천

검색

자료유형: 학술저널

저자정보: Faheem Farooq (Stony Brook University Hospital) Kevin Zarrabi (Stony Brook University Hospital) Keith Sweeney (Stony Brook University Hospital) 김요셉 (스토니브룩대학병원) Jela Bandovic (Stony Brook University Hospital) Chiraag Patel (Stony Brook University Hospital) 최민식 (스토니브룩대학병원)

저널정보: 대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제18권 제2호

발행연도: 2018.6

수록면: 200 - 207 (8page)

DOI: https://doi.org/10.5230/jgc.2018.18.e16

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Mixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs) are a group of rare tumors previously known as mixed adenoneuroendocrine carcinomas (MANECs). The neuroendocrine component is high-grade and may consist of small-cell carcinoma or large-cell neuroendocrine carcinoma. The nonneuroendocrine component may consist of adenocarcinoma or squamous cell carcinoma. We report a unique case of a MiNEN with trilineage differentiation: large-cell neuroendocrine carcinoma, squamous cell carcinoma, and adenocarcinoma. The reported patient presented with symptoms of an upper gastrointestinal bleed and was ultimately diagnosed with a MiNEN with trilineage differentiation. This is the first report of this exceedingly rare tumor type to include next-generation sequencing of the 3 separate tumor entities. In addition, we review the current literature and discuss the role of next-generation sequencing in classifying and treating MiNEN tumors.

#Neuroendocrine neoplasm #Gastric cancer #Precision medicine

참고문헌 (26)

참고문헌 신청

Lloyd RV / 2017 / WHO Classification of Tumours of Endocrine Organs / International Agency for Research on Cancer

Brathwaite S / 2016 / Appendiceal mixed adeno-neuroendocrine carcinoma: a population-based study of the Surveillance, Epidemiology, and End Results registry / Front Oncol 6:148

Sefr R / 2017 / Mixed adenoneuroendocrine carcinoma (MANEC) of the gastrointestinal tract / Rozhl Chir 96:41~44

La Rosa S / 2012 / Colorectal poorly differentiated neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas: insights into the diagnostic immunophenotype, assessment of methylation profile, and search for prognostic markers / Am J Surg Pathol 36:601~611

Bang YJ / 2012 / Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial / Lancet 379:315~321

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!