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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제52권 제4호
- 발행연도
- 2018.1
- 수록면
- 232 - 237 (6page)
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Primary combined hepatocellular carcinoma (HCC) and neuroendocrine carcinoma is a rare entity, and so is hypercalcemia due to ectopic parathyroid hormone (PTH) secretion by tumor. A 44-year-old man with hepatitis B virus associated chronic liver disease presented with a hepatic mass. Hemihepatectomy discovered the mass as combined HCC and poorly differentiated cholangiocarcinoma. During adjuvant chemoradiation therapy, he presented with nausea, and multiple systemic metastases were found. Laboratory tests revealed hypercalcemia with markedly elevated PTH and neuron specific enolase. Parathyroid scan showed normal uptake in parathyroid glands, suggestive of ectopic PTH secretion. Subsequently, immunohistochemistry of neuroendocrine marker was performed on the primary lesion, and confirmed the neuroendocrine differentiation in non-HCC component. The patient died 71 days after surgery. This report may suggest the possibility of ectopic PTH secretion by neuroendocrine carcinoma of hepatic origin causing hypercalcemia. Caution for neuroendocrine differentiation should be exercised when diagnosing poorly differentiated HCC.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Nomura Y / 2017 / Clinicopathological features of neoplasms with neuroendocrine differentiation occurring in the liver / J Clin Pathol 70:563~570
Barsky SH / 1984 / Hepatocellular carcinoma with carcinoid features / Hum Pathol 15:892~894
Artopoulos JG / 1994 / Primary mixed hepatocellular carcinoma with carcinoid characteristics: a case report / Hepatogastroenterology 41:442~444
Ishida M / 2003 / Primary hepatic neuroendocrine carcinoma coexisting with hepatocellular carcinoma in hepatitis C liver cirrhosis: report of a case / Surg Today 33:214~218
Yamaguchi R / 2004 / Hepatocellular carcinoma with an unusual neuroendocrine component / Pathol Int 54:861~865
Barsky SH / 1984 / Hepatocellular carcinoma with carcinoid features / Hum Pathol 15:892~894
Artopoulos JG / 1994 / Primary mixed hepatocellular carcinoma with carcinoid characteristics: a case report / Hepatogastroenterology 41:442~444
Ishida M / 2003 / Primary hepatic neuroendocrine carcinoma coexisting with hepatocellular carcinoma in hepatitis C liver cirrhosis: report of a case / Surg Today 33:214~218
Yamaguchi R / 2004 / Hepatocellular carcinoma with an unusual neuroendocrine component / Pathol Int 54:861~865
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