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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제41권 제5호
- 발행연도
- 2007.1
- 수록면
- 324 - 328 (5page)
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초록· 키워드
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Epithelial-mesenchymal transition (EMT) is critical for morphogenesis during
embryonic development and is also implicated in the conversion of early-stage tumors into
invasive malignancies. Recently, Twist has been identified to play an important role in EMTmediated
metastatic progression of several types of human cancer. The present study examined
the expression of Twist and evaluated its clinicopathologic significance in urothelial carcinoma
of upper urinary tract. Methods : Immunohistochemical staining for Twist expression
was performed on 70 upper urinary tract urothelial carcinomas (UUT-UCs) using tissue microarray.
Results : Immunohistochemical staining for Twist was positive in 31/70 cases (44.3%)
of UUT-UCs. Twist expression was associated with high-grade and advanced-stage (ISUP
grade, p<0.01; stage, p=0.045). The patients with Twist positive-tumors revealed lower disease
free survival rate than those with Twist negative-tumors (p<0.01). The overall survival
for patients with Twist positive-tumors was slightly worse than the patients with Twist negative-
tumors, but the difference was not statistically significant (p=0.12). Conclusion : Our
results suggest that Twist is a novel marker for advanced UUT-UC.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
/ / The twist gene isolation ofa Drosophila zygotic gene necessary for the establishment of dorsoventralpattern. Nucleic Acids Res 1987 : 3439 ~ 53
/ 1995 / Transitional cell carcinoma of the renal pelvis or ureter patterns of failure 46 : 796 ~ 800
/ 1997 / Mutations in TWIST, a basic helix-loop-helix transcription factor 15 : 36 ~ 41
/ 1998 / Urinary system 72 : 316 ~ 329
/ 1999 / Twist is a potential oncogene that inhibits apoptosis 13 : 2207 ~ 2217
/ 1995 / Transitional cell carcinoma of the renal pelvis or ureter patterns of failure 46 : 796 ~ 800
/ 1997 / Mutations in TWIST, a basic helix-loop-helix transcription factor 15 : 36 ~ 41
/ 1998 / Urinary system 72 : 316 ~ 329
/ 1999 / Twist is a potential oncogene that inhibits apoptosis 13 : 2207 ~ 2217
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