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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제44권 제5호
- 발행연도
- 2010.1
- 수록면
- 469 - 476 (8page)
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초록· 키워드
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Background : The epithelial mesenchymal transition (EMT) is intimately associated with tumor hypoxia. The present study was conducted to investigate the immunohistochemical relationship between hypoxic and EMT-related molecules in non-small cell lung carcinoma (NSCLC). Methods : Immunohistochemical staining for hypoxia inducible factor (HIF)-1α, carbonic anhydrase (CA) IX, TWIST, and E-cadherin proteins was performed in 146 cases of NSCLC (80 cases of adenocarcinoma and 66 cases of squamous cell carcinoma) using tissue microarray blocks. Results : HIF-1α, TWIST, CA IX, and E-cadherin were expressed in 58 (40%), 90 (62%), 82 (56%), and 36 (25%) of 146 NSCLC cases, respectively. TWIST expression was positively correlated with HIF-1α expression (p = 0.03) and inversely correlated with E-cadherin expression (p < 0.01). TWIST and CA IX expression were not significantly interrelated, but each showed a relationship with histological tumor grade. However, the expression of these molecules had no significant effect on clinical staging or patient survival. Conclusions : Although TWIST expression was correlated positively with HIF-1α expression and inversely correlated with E-cadherin, HIF-1α expression was not associated with E-cadherin expression. However, considering the relationship between HIF-1α and TWIST expression, further studies should be performed to demonstrate the role of hypoxia-induced EMT in NSCLC.
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참고문헌 (24)
참고문헌 신청
Arumugam T / 2009 / Epithelial to mes
Elloul S / 2005 / Snail,Slug,and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma / Cancer 103 : 1631 ~ 164
Giatromanolaki A / 2001 / Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and surv
Giatromanolaki A / 2003 / DEC1(STRA13)protein expression relates to hypoxia-inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer /
Kim SJ / 2005 / Expression of HIF-1alpha,CA IX,VEGF,and MMP-9 in surgically resected non-small cell lung cancer / Lung Cancer 49 : 325 ~ 335
Elloul S / 2005 / Snail,Slug,and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma / Cancer 103 : 1631 ~ 164
Giatromanolaki A / 2001 / Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and surv
Giatromanolaki A / 2003 / DEC1(STRA13)protein expression relates to hypoxia-inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer /
Kim SJ / 2005 / Expression of HIF-1alpha,CA IX,VEGF,and MMP-9 in surgically resected non-small cell lung cancer / Lung Cancer 49 : 325 ~ 335
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