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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제18권 제3호
- 발행연도
- 2008.1
- 수록면
- 228 - 235 (8page)
이용수
초록· 키워드
오류제보하기
Purpose : Our objective was to investigate the role of CD8＋ T cells in pathogenesis of wheezing in children with atopic nature.
Methods : Twelve atopic wheezers, 8 nonatopic wheezers, 8 disease controls and 8 healthy controls were enrolled in the study. We isolated CD8＋ T cells from peripheral blood samples, incubated them for 72 hours either in the absence or presence of phytohemagglutinin (PHA) and compared the concentrations of interleukin (IL)-5, IL-13, and interferon (IFN)-γ in the cell culture supernatants.
Results : In the atopic wheezer group, the IL-5 concentration was significantly higher after PHA stimulation than after non-stimulated incubation. This difference was not observed in the nonatopic wheezer, disease control and healthy control groups. IL-13 was undetectable in all of the cell culture supernatants. There was no significant difference in the IFN-γ concentration between the PHA-stimulated and non-stimulated conditions in all 4 groups.
Conclusion : The results of this study suggest that CD8＋ T cells may play a role in the pathogenesis of wheezing in children with atopic nature through the production of IL-5.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Borish L / 2004 / Cytokines in Allergic Inflammation. In: Middletons Allergy: Principles and Practice / St. Louise: Mosby : 135 ~ 157
Cho SH / 2002 / Peripheral blood CD4＋ and CD8＋ T cell type 1 and type 2 cytokine production in atopic asthmatic and normal subjects / Clin Exp Allergy 32 : 427 ~ 433
Cho SH / 2005 / Increased interleukin-4, interleukin-5, and interferon-γ in airway CD4＋ and CD8＋ T cells in atopic asthma / Am J Respir Crit Care Med 171 : 224 ~ 230
Coyle AJ / 1995 / Virus-specific CD8＋ cells can switch to interleukin 5 production and induce airway eosinophilia / J Exp Med 181 : 1229 ~ 1233
Croft M / 1994 / Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytoki
Cho SH / 2002 / Peripheral blood CD4＋ and CD8＋ T cell type 1 and type 2 cytokine production in atopic asthmatic and normal subjects / Clin Exp Allergy 32 : 427 ~ 433
Cho SH / 2005 / Increased interleukin-4, interleukin-5, and interferon-γ in airway CD4＋ and CD8＋ T cells in atopic asthma / Am J Respir Crit Care Med 171 : 224 ~ 230
Coyle AJ / 1995 / Virus-specific CD8＋ cells can switch to interleukin 5 production and induce airway eosinophilia / J Exp Med 181 : 1229 ~ 1233
Croft M / 1994 / Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytoki
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