지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Colorectal cancer is one of the most common alimentary malignancies. In this study, the antitumor activity of activated human natural killer (NK) cells against human colorectal cancer was evaluated in vivo. Human NK cells are the key contributors of innate immune response and the effective functions of these cells are enhanced by cytokines. Human peripheral blood mononuclear cells (PBMC) were cultured with interleukin-2 (IL-2)-containing medium for 14 days and resulted in enriched NK cell population. The resulting populations of the cells comprised 7% $CD3^+CD4^+$ cells, 25% $CD3^+CD8^+$ cells, 13% $CD3^-CD8^+$ cells, 4% $CD3^+$CD16/$CD56^+$ cells, 39% $CD3^+$CD16/$CD56^-$ cells, and 52% $CD3^-$CD16/$CD56^+$ cells. Tumor necrosis factor alpha (TNF-$\alpha$), interferon gamma (IFN-$\gamma$), IL-2, IL-4, and IL-5 transcripts of the activated NK cells were confirmed by RT-PCR. In addition, activated NK cells at doses of 2.5, 5 and 10 million cells per mouse inhibited 10%, 34% and 47% of SW620-induced tumor growth in nude mouse xenograft assays, respectively. This study suggests that NK cell-based immunotherapy may be used as an adoptive immunotherapy for colorectal cancer patients.
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참고문헌 (50)
참고문헌 신청
Davis, D. L / 1990 / International trends in cancer mortality in France, West Germany, Italy,Japan, England and Wales, and the USA / Lancet 336:474
Jemal, A / 2008 / Cancer statistics, 2008. CA Cancer / J. Clin 58:71
Bar-Sela, G / 2004 / Abnoba-viscum (mistletoe extract)in metastatic colorectal carcinoma resistant to 5-fluorouracil and leucovorin-based chemotherapy / Med. Oncol 21:251
de Gramont, A / 2005 / First-line therapy for advanced colorectal cancer / Curr. Oncol. Rep 7:167
Joosten, J / 2005 / Cryosurgery and radiofrequency ablation for unresectable colorectal liver metastases / Eur. J. Surg. Oncol 31:1152
Jemal, A / 2008 / Cancer statistics, 2008. CA Cancer / J. Clin 58:71
Bar-Sela, G / 2004 / Abnoba-viscum (mistletoe extract)in metastatic colorectal carcinoma resistant to 5-fluorouracil and leucovorin-based chemotherapy / Med. Oncol 21:251
de Gramont, A / 2005 / First-line therapy for advanced colorectal cancer / Curr. Oncol. Rep 7:167
Joosten, J / 2005 / Cryosurgery and radiofrequency ablation for unresectable colorectal liver metastases / Eur. J. Surg. Oncol 31:1152
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