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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 200 - 205 (6page)
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초록· 키워드
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Background and Purpose Optical coherence tomography (OCT) and visual evoked potentials(VEPs) can be used to detect optic neuritis (ON). However, the comparative sensitivities ofOCT and VEPs for detecting ON in neuromyelitis optica spectrum disorder (NMOSD) are unclear,and so we assessed these sensitivities. Methods This cross-sectional study included 73 patients with aquaporin-4 antibody-seropositiveNMOSD, and 101 eyes with ON. The clinical characteristics, visual acuity (VA), ExpandedDisability Status Scale (EDSS) scores, OCT peripapillary retinal nerve fiber layer (RNFL) thickness,and VEPs of the patients were evaluated. Results OCT and VEPs were abnormal in 68% and 73% of eyes with a history of ON, respectively,and in 2% and 9% of eyes without ON. Test sensitivities were influenced by the numberof ON episodes: the OCT RNFL thickness and VEPs were abnormal in 50% and 67% of theeyes with first-ever ON episode, respectively (p=0.041), with the combination of both tests detectingabnormalities in up to 75% of the eyes. The sensitivities of the OCT RNFL thickness andVEPs increased to 95% and 83%, respectively, after the second or subsequent ON episode(p=0.06), with the combination of both tests detecting abnormalities in 95% of cases. The OCTRNFL thickness and VEP latency/amplitude were correlated with EDSS scores and VA. Conclusions VEPs were superior for detecting subclinical or first-ever ON, while OCT wasbetter for detecting eyes with multiple ON episodes. The correlations of OCT and VEPs with clinicaldisability measures indicate that these tests are potential markers of the disease burden inNMOSD.
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참고문헌 (21)
참고문헌 신청
Pfueller CF / 2011 / Imaging the visual pathway in neuromyelitis optica / Mult Scler Int 2011:869814
Wingerchuk DM / 2015 / International consensus diagnostic criteria for neuromyelitis optica spectrum disorders / Neurology 85:177~189
Filippi M / 2016 / MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines / Lancet Neurol 15:292~303
Naismith RT / 2009 / Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis / Neurology 73:46~52
Naismith RT / 2009 / Optical coherence tomography differs in neuromyelitis optica compared with multiple sclerosis / Neurology 72:1077~1082
Wingerchuk DM / 2015 / International consensus diagnostic criteria for neuromyelitis optica spectrum disorders / Neurology 85:177~189
Filippi M / 2016 / MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines / Lancet Neurol 15:292~303
Naismith RT / 2009 / Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis / Neurology 73:46~52
Naismith RT / 2009 / Optical coherence tomography differs in neuromyelitis optica compared with multiple sclerosis / Neurology 72:1077~1082
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