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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 122 - 131 (10page)
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초록· 키워드
오류제보하기
Tourette syndrome is a childhood-onset disorder characterized by a combination of motor andvocal tics, ofen associated with psychiatric comorbidities including attention defcit and hyperactivity disorder and obsessive-compulsive disorder. Despite an onset early in life, half of patients may present symptoms in adulthood, with variable degrees of severity. In select cases,the syndrome may lead to signifcant physical and social impairment, and a worrisome riskfor self injury. Evolving research has provided evidence supporting the idea that the pathophysiology of Tourette syndrome is directly related to a disrupted circuit involving the cortexand subcortical structures, including the basal ganglia, nucleus accumbens, and the amygdala.
Tere has also been a notion that a dysfunctional group of neurons in the putamen contributes to an abnormal facilitation of competing motor responses in basal ganglia structures ultimately underpinning the generation of tics. Surgical therapies for Tourette syndrome have beenreserved for a small group of patients not responding to behavioral and pharmacological therapies, and these therapies have been directed at modulating the underlying pathophysiology.
Lesion therapy as well as deep brain stimulation has been observed to suppress tics in at leastsome of these cases. In this article, we will review the clinical aspects of Tourette syndrome, aswell as the evolution of surgical approaches and we will discuss the evidence and clinical responses to deep brain stimulation in various brain targets. We will also discuss ongoing research and future directions as well as approaches for open, scheduled and closed loop feedback-driven electrical stimulation for the treatment of Tourette syndrome.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
/ 1993 / Definitions and classification of tic disorders / Arch Neurol 50 : 1013 ~ 1016
Ackermans L / 2011 / Double-blind clinical trial of thalamic stimulation in patients with Tourette syndrome / Brain 134 : 832 ~ 844
Ball T / 2007 / Response properties of human amygdala subregions: evidence based on functional MRI combined with probabilistic anatomical maps / PLoS One 2 : e307 ~
Baym CL / 2008 / Neural correlates of tic severity and cognitive control in children with Tourette syndrome / Brain 131 : 165 ~ 179
Cannon E / 2012 / Deep brain stimulation of anteromedial globus pallidus interna for severe Tourette’s syndrome / Am J Psychia
Ackermans L / 2011 / Double-blind clinical trial of thalamic stimulation in patients with Tourette syndrome / Brain 134 : 832 ~ 844
Ball T / 2007 / Response properties of human amygdala subregions: evidence based on functional MRI combined with probabilistic anatomical maps / PLoS One 2 : e307 ~
Baym CL / 2008 / Neural correlates of tic severity and cognitive control in children with Tourette syndrome / Brain 131 : 165 ~ 179
Cannon E / 2012 / Deep brain stimulation of anteromedial globus pallidus interna for severe Tourette’s syndrome / Am J Psychia
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