지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 42 - 47 (6page)
이용수
초록· 키워드
오류제보하기
Background and Purpose The aim of this study was to determine the changes in diffusiontensor images associated with medication-related impulse control disorder (ICD) in Parkinson’sdisease (PD) patients undergoing chronic dopamine-replacement therapy.
Methods Nineteen PD patients, comprising 10 with ICD (PD-ICD) and 9 without ICD (PDnonICD), and 18 age-matched healthy controls (HCs) with no cognitive or other psychiatricdisorders were analyzed. All subjects underwent 3-T magnetic resonance diffusion-tensor imaging. For all PD patients, clinical data on PD duration, antiparkinsonian medication dosages,Unified Parkinson’s Disease Rating Scale and Mini-Mental State Examination were collected.
Whole-brain voxel-based measures of fractional anisotropy (FA) and mean diffusivity (MD)were analyzed.
Results In comparison with HCs, the PD-nonICD subjects had low FA at the bilateral orbitofrontal areas. While the PD-ICD subjects exhibited no such difference, their FA was significantly elevated at the anterior corpus callosum. Analysis of FA between the two PD groups revealed that FA in the anterior corpus callosum, right internal capsule posterior limbs, rightposterior cingulum, and right thalamic radiations were significantly higher (corrected p<0.05)in the PD-ICD than in the PD-nonICD patients. MD did not differ between the PD-ICD andPD-nonICD groups in any brain regions.
Conclusions The PD-ICD patients appear to have relatively preserved white-matter integrityin the regions involved in reward-related behaviors compared to PD-nonICD patients. Furtherinvestigation is required to determine whether the difference in FA between PD-ICD and PDnonICD patients reflects microstructural differences in the pathological progression of PD or issecondary to ICD.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Cilia R / 2008 / Functional abnormalities underlying pathological gambling in Parkinson disease / Arch Neurol 65 : 1604 ~ 1611
Grant JE / 2006 / The neurobiology of substance and behavioral addictions / CNS Spectr 11 : 924 ~ 930
Joutsa J / 2012 / Increased medial orbitofrontal [18F]fluorodopa uptake in Parkinsonian impulse control disorders / Mov Disord 27 : 778 ~ 782
Lawrence AD / 2003 / Compulsive use of dopamine replacement therapy in Parkinson’s disease: reward systems gone awry? / Lancet Neurol 2 : 595 ~ 604
Lee JY / 2010 / Association between the dose of dopaminergic medication and the behavioral disturbances in Parkinson disease / Parkinsonism Relat Disord 16 : 202 ~ 207
Grant JE / 2006 / The neurobiology of substance and behavioral addictions / CNS Spectr 11 : 924 ~ 930
Joutsa J / 2012 / Increased medial orbitofrontal [18F]fluorodopa uptake in Parkinsonian impulse control disorders / Mov Disord 27 : 778 ~ 782
Lawrence AD / 2003 / Compulsive use of dopamine replacement therapy in Parkinson’s disease: reward systems gone awry? / Lancet Neurol 2 : 595 ~ 604
Lee JY / 2010 / Association between the dose of dopaminergic medication and the behavioral disturbances in Parkinson disease / Parkinsonism Relat Disord 16 : 202 ~ 207
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