지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 112 - 117 (6page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaPanic disorder (PD) is a common psychiatric disorder with a complex etiology, and several studies have suggested that it has a genetic component. Brain-derived neurotrophic factor (BDNF) is the most abundant of the neurotrophins in the brain and is recognized for its important role in the survival, differentiation and growth of neurons. Several lines of research have suggested possible associations between the BDNF gene and PD. In this study, we investigated the BDNF 196G/A (rs6265), 11757G/C (rs16917204), and 270C/T (rs56164415) single nucleotide polymorphisms (SNPs) in order to determine an association with PD. We also identified the genetic sequence associations with PD via haplotype analysis.
MethodsaaParticipants in this study included 136 PD patients and 263 healthy controls. Male and female subjects were analyzed separately. The genotype and allele frequencies of the PD patients and controls were analyzed using χ2 statistics. Frequencies and haplotype reconstructions were calculated using the SNP analyzer 2.0.
ResultsaaWe found no significant statistical differences in the genotype distributions or allele frequencies of the three tested polymorphisms between the PD and control groups. In addition, no differences were found between PD patients and the controls in either male or female subgroups. However, we found that, the frequency of the G-C haplotype for 196G/A and 11757G/C was significantly higher in PD patients than in the controls.
ConclusionaaOur result suggest that patients with the G-C haplotype for 196G/A and 11757G/C may be more susceptible to the development of PD. Further studies are needed to replicate the associations that we observed.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Ashe PC / 2001 / Schizophrenia, a neurodegenerative disorder with neurodevelopmental antecedents / Prog Neuropsychopharmacol Biol Psychiatry 25 : 691 ~ 707
Boiocchi C / 2013 / Brain-derived neurotrophic factor gene variants and Alzheimer disease: an association study in an Alzheimer disease Italian population / Rejuvenation Res
Bun-Hee Lee / 2010 / The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment / PSYCHIATRY INVESTIGATION 7 (4) : 231 ~ 235
Egan MF / 2003 / The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function / Cell 112 : 257 ~ 269
First M / 1998 / Structured Clinical Interview for DSM IV Axis I Disorder Patient Edition / New York State Psychiatric Institute
Boiocchi C / 2013 / Brain-derived neurotrophic factor gene variants and Alzheimer disease: an association study in an Alzheimer disease Italian population / Rejuvenation Res
Bun-Hee Lee / 2010 / The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment / PSYCHIATRY INVESTIGATION 7 (4) : 231 ~ 235
Egan MF / 2003 / The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function / Cell 112 : 257 ~ 269
First M / 1998 / Structured Clinical Interview for DSM IV Axis I Disorder Patient Edition / New York State Psychiatric Institute
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