지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 754 - 761 (8page)
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초록· 키워드
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Objective: Extrapyramidal signs (EPS) are common in patients with mild cognitive impairment (MCI). However, few studies have assessed the effect of EPS on the clinical course of MCI. We aimed to evaluate whether patients with EPS show more frequent progression from MCI to Alzheimer’s disease (AD) and to other types of dementia.
Methods: Participants (n=882) with MCI were recruited, and were followed for up to 5 years. The EPS positive group was defined by the presence of at least one EPS based on a focused neurologic examination at baseline.
Results: A total of 234 converted to dementia during the follow-up period. The risk of progression to AD was lower in the patients with EPS after adjusting for potential confounders [hazard ratio (HR)=0.70, 95% confidence interval (CI)=0.53–0.93, p=0.01]. In contrast, the patients with EPS had a six-fold elevated risk of progression to dementia other than AD (HR=6.33, 95%CI=2.30–17.39, p<0.001).
Conclusion: EPS in patients with MCI is a strong risk factor for progression of MCI to non-Alzheimer dementia. The careful neurologic examination for EPS in patients with MCI can yield important clinical information for prognosis.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Artero S / 2008 / Risk profiles for mild cognitive impairment and progression to dementia are gender specific / J Neurol Neurosurg Psychiatry 79 : 979 ~ 984
Bennett DA / 1996 / Prevalence of parkinsonian signs and associated mortality in a community population of older people / N Engl J Med 334 : 71 ~ 76
Busse A / 2006 / Mild cognitive impairment : long-term course of four clinical subtypes / Neurology 67 : 2176 ~ 2185
Choi J / 2013 / Association between functional impairment, depression, and extrapyramidal signs in neuroleptic-free patients with Alzheimer disease / J Geriatr Psychiatry Ne
Farias ST / 2009 / Progression of mild cognitive impairment to dementia in clinic-vs community-based cohorts / Arch Neurol 66 : 1151 ~ 1157
Bennett DA / 1996 / Prevalence of parkinsonian signs and associated mortality in a community population of older people / N Engl J Med 334 : 71 ~ 76
Busse A / 2006 / Mild cognitive impairment : long-term course of four clinical subtypes / Neurology 67 : 2176 ~ 2185
Choi J / 2013 / Association between functional impairment, depression, and extrapyramidal signs in neuroleptic-free patients with Alzheimer disease / J Geriatr Psychiatry Ne
Farias ST / 2009 / Progression of mild cognitive impairment to dementia in clinic-vs community-based cohorts / Arch Neurol 66 : 1151 ~ 1157
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