지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,174 - 1,180 (7page)
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초록· 키워드
오류제보하기
Objective Structural changes of brain areas have been reported in depressive disorder and suicidal behavior (SB), in which TPH1 also has been known as a promising candidate gene. We investigated gray matter volume (GMV) differences, TPH1 rs1800532 and rs1799913 polymorphisms previously found to be associated with depressive disorder and SB, and the relationship between the two markers. Methods Thirteen depressive disorder patients with suicidal attempts (SA) and twenty healthy controls were included. We examined GMV differences using a voxel-based morphometry and regions of interest analysis. Direct sequencing was used for genotyping. Results The patients showed significant GMV reduction in left cerebral region including middle frontal gyrus, inferior frontal gyrus, and anterior cingulate cortex; in right middle temporal gyrus; in left cerebellar tonsil; and in right cerebral region including precentral gyrus and postcentral gyrus (corrected p<0.005). The right precentral and postcentral gyri GMV values of AA and CA genotypes patients were significantly decreased compared to those of CC genotype subjects (corrected p=0.040). Conclusion These findings show the possibility that both GMV reductions and TPH1 rs1800532/rs1799913 A allele may be involved in the pathogenesis of depressive disorder patients with SA.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
World Health Organization / 2017 / Depression and Other Common Mental Disorders: Global Health Estimates / World Health Organization
Zhang FF / 2018 / Brain structure alterations in depression: psychoradiological evidence / CNS Neurosci Ther 24:994~1003
van Eijndhoven P / 2013 / Paralimbic cortical thickness in first-episode depression:evidence for trait-related differences in mood regulation / Am J Psychiatry 170:1477~1486
Jia Z / 2014 / Impaired frontothalamic circuitry in suicidal patients with depression revealed by diffusion tensor imaging at 3.0 T / J Psychiatry Neurosci 39:170~177
Peng W / 2016 / Essential brain structural alterations in major depressive disorder: a voxel-wise meta-analysis on first episode, medication-naive patients / J Affect Disord 199:114~123
Zhang FF / 2018 / Brain structure alterations in depression: psychoradiological evidence / CNS Neurosci Ther 24:994~1003
van Eijndhoven P / 2013 / Paralimbic cortical thickness in first-episode depression:evidence for trait-related differences in mood regulation / Am J Psychiatry 170:1477~1486
Jia Z / 2014 / Impaired frontothalamic circuitry in suicidal patients with depression revealed by diffusion tensor imaging at 3.0 T / J Psychiatry Neurosci 39:170~177
Peng W / 2016 / Essential brain structural alterations in major depressive disorder: a voxel-wise meta-analysis on first episode, medication-naive patients / J Affect Disord 199:114~123
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