개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 108 - 111 (4page)
이용수
초록· 키워드
오류제보하기
Objective: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. Because the TH Val81Met polymorphism is located in the amino-terminal regulatory domain of the tetrameric enzyme, it is a candidate marker for susceptibility to dopamine-related traits. We investigated the hypothesis that TH Val81Met polymorphism can influence susceptibility to tardive dyskinesia (TD) in schizophrenia.
Methods: TH Val81Met polymorphism was analyzed by PCR-based methods in 83 schizophrenic patients with TD and 126 schizophrenic patients without TD, matched for antipsychotic drug exposure and other relevant variables.
ResultsaaThere was no significant association of the genotype and allele requencies determined by the TH Val81Met polymorphism between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups.
Conclusion: Within the limitations imposed by the size of the clinical sample, these findings suggest that the Val81Met polymorphism of the TH gene does not contribute significantly to the risk for TD.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Andreassen OA / 2000 / Neurotoxicity associated with neuroleptic-induced oral dyskinesias in rats. Implications for tardive dyskinesia? / Prog Neurobiol 61 : 525 ~ 541
Ankenman R / 2007 / Low dose alpha-methyl-para-tyrosine (AMPT) in the treatment of dystonia and dyskinesia / J Neuropsychiatry Clin Neurosci 19 : 65 ~ 69
Bloomquist J / 1994 / 1-Methyl-4-phenylpyridinium-like neurotoxicity of a pyridinium metabolite derived from haloperidol: cell culture and n
Casey DE / 1980 / gamma-Acetylenic GABA in tardive dyskinesia / Arch Gen Psychiatry 37 : 1376 ~ 1379
Flatmark T / 1999 / Structural insight into the aromatic amino acid hydroxylases and their disease-related mutant forms / Chem Rev 99 : 2137 ~ 2160
Ankenman R / 2007 / Low dose alpha-methyl-para-tyrosine (AMPT) in the treatment of dystonia and dyskinesia / J Neuropsychiatry Clin Neurosci 19 : 65 ~ 69
Bloomquist J / 1994 / 1-Methyl-4-phenylpyridinium-like neurotoxicity of a pyridinium metabolite derived from haloperidol: cell culture and n
Casey DE / 1980 / gamma-Acetylenic GABA in tardive dyskinesia / Arch Gen Psychiatry 37 : 1376 ~ 1379
Flatmark T / 1999 / Structural insight into the aromatic amino acid hydroxylases and their disease-related mutant forms / Chem Rev 99 : 2137 ~ 2160
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
지연성 운동장애와 BDNF(Brain-derived Neurotrophic Factor) Val66Met 유전자 다형성과의 연관성연구
생물치료정신의학
2006 .06
-
정신분열병환자에서 만발성 운동장애와 $5-HT_6$ 수용체 유전자 다형성(267C/T)과의 관계
생물정신의학
2004 .01
-
Effect of the Presence of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on the Recovery in Patients With Acute Subcortical Stroke
Annals of Rehabilitation Medicine
2013 .01
-
지연성 운동장애와 5-$HT_{2A}$ 수용체 유전자 T103C 다형성과의 관계
생물정신의학
2003 .01
-
Lack of Associations of the COMT Val158Met Polymorphism with Risk of Endometrial and Ovarian Cancer: a Pooled Analysis of Case-control Studies
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
No Association between Dopamine D3 Receptor Gene Ser9Gly Polymorphism and Tardive Dyskinesia in Schizophrenia
Clinical Psychopharmacology and Neuroscience
2008 .01
-
Association between the Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Alexithymia in Patients with Obsessive-Compulsive Disorder
Yonsei Medical Journal
2016 .01
-
Association of the Brain-derived Neurotrophic Factor Gene and Clinical Features of Bipolar Disorder in Korea
Clinical Psychopharmacology and Neuroscience
2012 .01
-
한국인 정신분열병 환자의 안구추적운동 이상과 COMT 유전자의 Val108/158Met 다형성의 연합 연구
생물정신의학
2008 .01
-
Brain-Derived Neurotrophic Factor Val66Met 다형성과 정신분열병의 관련 연구
생물정신의학
2006 .01
-
No Evidence for an Association between Dopamine D2 Receptor Polymorphisms and Tardive Dyskinesia in Korean Schizophrenia Patients
PSYCHIATRY INVESTIGATION
2011 .01
-
The rs6265 Polymorphism of the BDNF Gene Is Related to Higher-Lethality Suicide Attempts in the Korean Population
PSYCHIATRY INVESTIGATION
2020 .01
-
Brain-Derived Neurotrophic Factor(BNDF) Val66Met 유전자 다형성과 성격 특성에 대한 연합연구
생물정신의학
2005 .01
-
Effects of Mind-Body Training on Personality and Behavioral Activation and Inhibition System According to BDNF Val66Met Polymorphism
PSYCHIATRY INVESTIGATION
2016 .01
-
Association between Antipsychotics-Induced Restless Legs Syndrome and Tyrosine Hydroxylase Gene Polymorphism
PSYCHIATRY INVESTIGATION
2009 .01
-
Gender-specific Associations of the Brain-derived Neurotrophic Factor Val66Met Polymorphism with Neurocognitive and Clinical Features in Schizophrenia
Clinical Psychopharmacology and Neuroscience
2016 .01
-
Association between the BDNF Val66Met Polymorphism and Chronicity of Depression
PSYCHIATRY INVESTIGATION
2013 .01
-
Impact of the BDNF Val66Met Polymorphism on Regional Brain Gray Matter Volumes: Relevance to the Stress Response
PSYCHIATRY INVESTIGATION
2013 .01
-
Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism Is a Risk Factor for Attention-Deficit Hyperactivity Disorder in a Turkish Sample
PSYCHIATRY INVESTIGATION
2016 .01
-
No Association between PAWR Gene Polymorphisms and Tardive Dyskinesia in Schizophrenia Patients
PSYCHIATRY INVESTIGATION
2012 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0