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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 125 - 135 (11page)
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ObjectiveaaThis article investigates subjects aged 55 to 65 from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database to broaden our understanding of early-onset (EO) cognitive impairment using neuroimaging and genetics biomarkers.
MethodsaaNine of the subjects had EO-AD (Alzheimer’s disease) and 27 had EO-MCI (mild cognitive impairment). The 15 most important neuroimaging markers were extracted with the Global Shape Analysis (GSA) Pipeline workflow. The 20 most significant single nucleotide polymorphisms (SNPs) were chosen and were associated with specific neuroimaging biomarkers.
ResultsaaWe identified associations between the neuroimaging phenotypes and genotypes for a total of 36 subjects. Our results for all the subjects taken together showed the most significant associations between rs7718456 and L_hippocampus (volume), and between rs7718456 and R_hippocampus (volume). For the 27 MCI subjects, we found the most significant associations between rs6446443 and R_superior_frontal_gyrus (volume), and between rs17029131 and L_Precuneus (volume). For the nine AD subjects, we found the most significant associations between rs16964473 and L_rectus gyrus (surface area), and between rs12972537 and L_rectus_gyrus (surface area).
ConclusionaaWe observed significant correlations between the SNPs and the neuroimaging phenotypes in the 36 EO subjects in terms of neuroimaging genetics. However, larger sample sizes are needed to ensure that the effects will be detectable for a reasonable false-positive error rate using the GSA and Plink Pipeline workflows.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Biffi A / 2010 / Genetic variation and neuroimaging measures in Alzheimer disease / Arch Neurol 67 : 677 ~ 685
Campion D / 1999 / Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum / Am J Hum Genet 65 : 664 ~ 670
Cannon TD / 2006 / Mapping heritability and molecular genetic associations with cortical features using probabilistic brain atlases: methods and applications to schizophreni
Dale AM / 1999 / Cortical surface-based analysis. I. Segmentation and surface reconstruction / Neuroimage 9 : 179 ~ 194
Desikan RS / 2009 / Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive i
Campion D / 1999 / Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum / Am J Hum Genet 65 : 664 ~ 670
Cannon TD / 2006 / Mapping heritability and molecular genetic associations with cortical features using probabilistic brain atlases: methods and applications to schizophreni
Dale AM / 1999 / Cortical surface-based analysis. I. Segmentation and surface reconstruction / Neuroimage 9 : 179 ~ 194
Desikan RS / 2009 / Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive i
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