지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives：Recently, irritable bowel syndrome (IBS) is known to be related with neurotransmitters. This study was
designed to determine β-adrenergic receptor function in patients with IBS and to compared with normal controls to examine
the relationship between β-adrenergic receptor function and anxiety in IBS patients.
Methods：Eighteen IBS patients were compared with the same number of age and sex-matched normal subjects in terms of
β-adrenergic receptor function and psychological variables reflecting anxiety levels. To assess β-adrenergic receptor function,
Chronotropic 25 dose (CD25) was calculated via isoproterenol stimulation test.
Results：CD25 values in the patient group were significantly lower than those in the control group, which reflected increased
β-adrenergic receptor function (2.19±1.08 versus 3.89±1.64, p<0.05). Patients with IBS showed higher HAM-A scores
(8.88±4.88 versus 3.59±2.65, p<0.01), HAM-D scores (6.41±4.02 versus 2.47±2.40, p<0.01), BDI scores (9.00±6.21
versus 4.72±4.30, p<0.05), and STAI scores (STAI-S：43.41±6.34 versus 33.83±8.18, p<0.01, STAI-T：44.65±7.43 versus
38.17±8.45, p<0.05). In addition, HAM-A scores were negatively correlated with CD25 values in the patient group (r=-0.424,
p<0.01).
Conclusion：These results suggest that β-adrenergic receptor function is increased in patients with IBS, which could affect
increased anxiety levels in these patients. (J Korean Neuropsychiatr Assoc 2004;43(1):40-45)
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
/ / Comparison of sympatho-adrenergicregulation at rest and of the adrenoceptor system in swimmers : 596 ~ 604
/ 1959 / The assessment of anxiety states by rating 32 : 50 ~ 55
/ 1970 / Illness experienceand life stresses in patients with irritable colon and with ulcerativecolitis 1 : 14 ~ 17
/ 1970 / STAI manual for the statetraitanxiety inventory
/ 1972 / A standardized isoproterenolsensitivity test 130 : 47 ~ 52
/ 1959 / The assessment of anxiety states by rating 32 : 50 ~ 55
/ 1970 / Illness experienceand life stresses in patients with irritable colon and with ulcerativecolitis 1 : 14 ~ 17
/ 1970 / STAI manual for the statetraitanxiety inventory
/ 1972 / A standardized isoproterenolsensitivity test 130 : 47 ~ 52
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