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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 382 - 390 (9page)
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Background/Aims: Previous studies have revealed that mast cells (MCs) may activate the protease-activated receptors and release of neuropeptides involved in the pathogenesis of irritable bowel syndrome (IBS). The levels of proteaseactivated receptor 2 (PAR-2) and tryptase can contribute to understanding the pathogenesis of IBS. Methods: Colonoscopic biopsies were performed of 38 subjects (20 with IBSdiarrhea [IBS-D], eight with IBS-constipation [IBS-C], and 10 healthy volunteers). The mRNA and protein levels of tryptase and PAR-2 were assessed by real-time PCR and Western blot.
The levels of vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gene-related peptide (CGRP) were measured by immunohistochemistry, and MCs were counted by toluidine blue staining. Results: Significant increases in the mRNA expression of tryptase (p<0.05, IBS-D, IBS-C vs control) and PAR-2 (p<0.05, IBS-D, IBS-C vs control) and in the tryptase protein level (p<0.05, IBS-D, IBS-C vs control) were detected in IBS. Elevations of MCs, CGRP, VIP and SP (p<0.05, IBS-D vs control) were observed for IBS-D only. Conclusions: Tryptase levels may upregulate the function of PAR- 2, resulting in the release of neuropeptide and they were correlated with clinical symptoms associated with IBS.
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참고문헌 (21)
참고문헌 신청
Martínez C / 2013 / Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier / Gut 62:1160~1168
Vivinus-Nébot M / 2012 / Combination of allergic factors can worsen diarrheic irritable bowel syndrome: role of barrier defects and mast cells / Am J Gastroenterol 107:75~81
Miller HR / 2002 / Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut / Immunology 105:375~390
Wilcz-Villega EM / 2013 / Mast cell tryptase reduces junctional adhesion molecule-A (JAM-A) expression in intestinal epithelial cells: implications for the mechanisms of barrier dysfunction in irritable bowel syndrome / Am J Gastroenterol 108:1140~1151
Cenac N / 2007 / Role for protease activity in visceral pain in irritable bowel syndrome / J Clin Invest 117:636~647
Vivinus-Nébot M / 2012 / Combination of allergic factors can worsen diarrheic irritable bowel syndrome: role of barrier defects and mast cells / Am J Gastroenterol 107:75~81
Miller HR / 2002 / Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut / Immunology 105:375~390
Wilcz-Villega EM / 2013 / Mast cell tryptase reduces junctional adhesion molecule-A (JAM-A) expression in intestinal epithelial cells: implications for the mechanisms of barrier dysfunction in irritable bowel syndrome / Am J Gastroenterol 108:1140~1151
Cenac N / 2007 / Role for protease activity in visceral pain in irritable bowel syndrome / J Clin Invest 117:636~647
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