지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 102 - 111 (10page)
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초록· 키워드
오류제보하기
ObjectiveaaEarly neuroimaging studies have demonstrated amygdala hypoactivation in schizophrenia but more recent research based on paradigms with minimal cognitive loads or examining automatic processing has observed amygdala hyperactivation. Hyperactivation was found to be related to affective flattening. In this study, amygdala responsivity to threat-related facial expression was investigated in patients as a function of automatic versus controlled processing and patients’ flat affect.
MethodsaaFunctional magnetic resonance imaging was used to measure amygdala activation in 36 patients with schizophrenia and 42 healthy controls. During scanning, a viewing task with masked and unmasked fearful and neutral faces was presented.
ResultsaaPatients exhibited increased amygdala response to unmasked fearful faces. With respect to masked fearful faces, no between-group differences emerged for the sample as a whole but a subsample of patients with flat affect showed heightened amygdala activation. The amygdala response to masked fearful faces was positively correlated with the degree of flat affect. Conversely, amygdala response to unmasked fearful faces was negatively correlated to the severity of affective flattening. In patients, amygdala responses to masked and unmasked fearful faces showed an inverse correlation.
ConclusionaaOur findings suggest that amygdala hyperresponsivity to unmasked fearful faces might be a functional characteristic of schizophrenia. Amygdala hyperresponsivity to masked fearful faces might be a specific characteristic of patients with affective flattening. A model of flat affect as a response mechanism to emotional overload is proposed.
목차
등록된 정보가 없습니다.
참고문헌 (47)
참고문헌 신청
Kring AM / 2008 / Emotional response deficits in schizophrenia : insights from affective science / Schizophr Bull 34:819~834
Andreasen NC / 1983 / Scale for the Assessment of Negative Symptoms (SANS) / University of Iowa
Burbridge JA / 2007 / Anhedonia and the experience of emotion in individuals with schizophrenia / J Abnorm Psychol 116:30~42
Herbener ES / 2007 / Failure of positive but not negative emotional valence to enhance memory in schizophrenia / J Abnorm Psychol 116:43~55
Kring AM / 1993 / Flat affect in schizophrenia does not reflect diminished subjective experience of emotion / J Abnorm Psychol 102:507~517
Andreasen NC / 1983 / Scale for the Assessment of Negative Symptoms (SANS) / University of Iowa
Burbridge JA / 2007 / Anhedonia and the experience of emotion in individuals with schizophrenia / J Abnorm Psychol 116:30~42
Herbener ES / 2007 / Failure of positive but not negative emotional valence to enhance memory in schizophrenia / J Abnorm Psychol 116:43~55
Kring AM / 1993 / Flat affect in schizophrenia does not reflect diminished subjective experience of emotion / J Abnorm Psychol 102:507~517
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