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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한자기공명의과학회 Investigative Magnetic Resonance Imaging Investigative Magnetic Resonance Imaging 제25권 제3호
- 발행연도
- 2021.9
- 수록면
- 164 - 171 (8page)
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Purpose: Mild cognitive impairment (MCI) is a prodromal stage of Alzheimer's disease (AD). Brain atrophy in this disease spectrum begins in the medial temporal lobe structure, which can be recognized by magnetic resonance imaging. To overcome the unsatisfactory inter-observer reliability of visual evaluation, quantitative brain volumetry has been developed and widely investigated for the diagnosis of MCI and AD. The aim of this study was to assess the prediction accuracy of quantitative brain volumetry using a fully automated segmentation software package, NeuroQuant®, for the diagnosis of MCI.
Materials and Methods: A total of 418 subjects from the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer’s Disease cohort were included in our study. Each participant was allocated to either a cognitively normal old group (n = 285) or an MCI group (n = 133). Brain volumetric data were obtained from T1- weighted images using the NeuroQuant software package. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to investigate relevant brain regions and their prediction accuracies.
Results: Multivariate logistic regression analysis revealed that normative percentiles of the hippocampus (P < 0.001), amygdala (P = 0.003), frontal lobe (P = 0.049), medial parietal lobe (P = 0.023), and third ventricle (P = 0.012) were independent predictive factors for MCI. In ROC analysis, normative percentiles of the hippocampus and amygdala showed fair accuracies in the diagnosis of MCI (area under the curve: 0.739 and 0.727, respectively).
Conclusion: Normative percentiles of the hippocampus and amygdala provided by the fully automated segmentation software could be used for screening MCI with a reasonable post-processing time. This information might help us interpret structural MRI in patients with cognitive impairment.
목차
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참고문헌 (36)
참고문헌 신청
Petersen RC / 2016 / Mild cognitive impairment / Continuum (Minneap Minn) 22:404~418
Jongsiriyanyong S / 2018 / Mild cognitive impairment in clinical practice : a review article / Am J Alzheimers Dis Other Demen 33:500~507
Rathakrishnan BG / 2014 / Science to practice : translating automated brain MRI volumetry in Alzheimer's disease from research to routine diagnostic use in the work-up of dementia / Front Neurol 4:216
Braak E / 1999 / Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? / Eur Arch Psychiatry Clin Neurosci 249(Suppl 3):14~22
Killiany RJ / 2002 / MRI measures of entorhinal cortex vs hippocampus in preclinical AD / Neurology 58:1188~1196
Jongsiriyanyong S / 2018 / Mild cognitive impairment in clinical practice : a review article / Am J Alzheimers Dis Other Demen 33:500~507
Rathakrishnan BG / 2014 / Science to practice : translating automated brain MRI volumetry in Alzheimer's disease from research to routine diagnostic use in the work-up of dementia / Front Neurol 4:216
Braak E / 1999 / Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? / Eur Arch Psychiatry Clin Neurosci 249(Suppl 3):14~22
Killiany RJ / 2002 / MRI measures of entorhinal cortex vs hippocampus in preclinical AD / Neurology 58:1188~1196
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