지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 907 - 913 (7page)
이용수
초록· 키워드
오류제보하기
Objective Previous studies reported the delayed recovery group after circadian rhythm disruption in mice showed higher quinpiroleinduced locomotor activity. This study aimed to compare not only Protein Kinase C (PKC) activities in frontal, striatal, hippocampus and cerebellum, but also relative PKC activity ratios among brain regions according to recovery of circadian rhythm. Methods The circadian rhythm disruption protocol was applied to eight-week-old twenty male Institute Cancer Research mice. The circadian rhythm recovery patterns were collected through motor activities measured by Mlog system. Depressive and manic proneness were examined by forced swim test and quinpirole-induced open field test respectively. Enzyme-linked immunosorbent assay was employed to measure PKC activities. Results The delayed recovery group presented greater locomotor activities than the early recovery group (p=0.033). The delayed recovery group had significantly lower frontal PKC activity than the other (p=0.041). The former showed lower frontal/cerebellar PKC activity ratio (p=0.047) but higher striatal/frontal (p=0.038) and hippocampal/frontal (p=0.007) PKC activities ratios than the latter. Conclusion These findings support potential mechanism of delayed recovery after circadian disruption in bipolar animal model could be an alteration of relative PKC activities among mood regulation related brain regions. It is required to investigate the PKC downstream signaling related to the delayed recovery pattern.
목차
등록된 정보가 없습니다.
참고문헌 (46)
참고문헌 신청
Murray G / 2010 / Circadian rhythms and sleep in bipolar disorder / Bipolar Disord 12:459~472
Malkoff-Schwartz S / 1998 / Stressful life events and social rhythm disruption in the onset of manic and depressive bipolar episodes: a preliminary investigation / Arch Gen Psychiatry 55:702~707
Geoffroy PA / 2015 / Sleep in patients with remitted bipolar disorders: a meta-analysis of actigraphy studies / Acta Psychiatr Scand 131:89~99
Serretti A / 2003 / Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism / Am J Med Genet B Neuropsychiatr Genet 121:35~38
Shi J / 2008 / Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm / Am J Med Genet B Neuropsychiatr Genet 147B:1047~1055
Malkoff-Schwartz S / 1998 / Stressful life events and social rhythm disruption in the onset of manic and depressive bipolar episodes: a preliminary investigation / Arch Gen Psychiatry 55:702~707
Geoffroy PA / 2015 / Sleep in patients with remitted bipolar disorders: a meta-analysis of actigraphy studies / Acta Psychiatr Scand 131:89~99
Serretti A / 2003 / Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism / Am J Med Genet B Neuropsychiatr Genet 121:35~38
Shi J / 2008 / Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm / Am J Med Genet B Neuropsychiatr Genet 147B:1047~1055
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
양극성장애 취약성 동물 모형으로서의 수면-각성 주기교란 후 정상화의 지연(양극성장애 취약성 동물 모형)
신경정신의학
2016 .01
-
Involvement of Protein Kinase C-δ in Vascular Permeability in Acute Lung Injury
Immune Network
2015 .08
-
Protein kinase C beta II upregulates intercellular adhesion molecule-1 via mitochondrial activation in cultured endothelial cells
The Korean Journal of Physiology & Pharmacology
2017 .07
-
Bipolar Disorder, Circadian Rhythm and Clock Genes
Clinical Psychopharmacology and Neuroscience
2024 .05
-
암의 생물학과 일주기 리듬의 교란
생물치료정신의학
2021 .10
-
일주기리듬의 조절이상이 양극성장애의핵심 발병 기전일까?
신경정신의학
2018 .01
-
정신질환 연구에서의 일주기 리듬 측정
생물치료정신의학
2020 .10
-
정신질환 연구에서의 일주기 리듬 분석
생물치료정신의학
2021 .02
-
Is Advancing Circadian Rhythm the Mechanism of Antidepressants?
PSYCHIATRY INVESTIGATION
2019 .01
-
The characteristics of circadian rhythm measurements in adolescents with depressive disorder
대한소아청소년정신의학회 학술대회논문집
2022 .11
-
The Effect of Circadian and Sleep Disruptions on Obesity Risk
Journal of Obesity & Metabolic Syndrome
2018 .01
-
Inhibition of angiotensin converting enzyme increases PKCβI isoform expression via activation of substance P and bradykinin receptors in cultured astrocytes of mice
Journal of Veterinary Science
2023 .03
-
Circadian Rhythms, Depressive and Anxiety Symptoms, and Chronotype: Interaction and Implication for Mental Health in Healthy Subjects
우울조울병
2024 .03
-
Optimization of Analysis of Circadian Rest-Activity Rhythm Using Cosinor Analysis in Mice
PSYCHIATRY INVESTIGATION
2022 .05
-
Knocking Down Nucleolin Expression Enhances the Radiosensitivity of Non-Small Cell Lung Cancer by Influencing DNA-PKcs Activity
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
PLCE1 Promotes the Invasion and Migration of Esophageal Cancer Cells by Up-Regulating the PKCα/NF-κB Pathway
Yonsei Medical Journal
2018 .01
-
Neurobiological Functions of the Period Circadian Clock 2 Gene, Per2
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes
Diabetes and Metabolism Journal
2024 .01
-
Fighting Against the Clock: Circadian Disruption and Parkinson’s Disease
Journal Of Movement Disorders
2024 .01
-
Influence of Circadian Disruption Associated With Artificial Light at Night on Micturition Patterns in Shift Workers
International Neurourology Journal
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0