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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 862 - 870 (9page)
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Purpose This study evaluates the long-term results of definitive radiotherapy (RT) for early glotticcancer. Clinical and treatment factors related to local control and patterns of failure areanalyzed.
Materials and MethodsWe retrospectively reviewed 222 patients with T1-2N0 squamous cell carcinoma of the glotticlarynx treated with definitive RT from 1981 to 2010. None of the patients received electivenodal RT or combined chemotherapy. The median total RT dose was 66 Gy. The dailyfraction size was < 2.5 Gy in 69% and 2.5 Gy in 31% of patients. The RT field extended fromthe hyoid bone to the cricoid cartilage.
ResultsThe median age was 60 years, and 155 patients (70%) had T1 disease. The 5-year rates oflocal recurrence-free survival (LRFS) and ultimate LRFS with voice preservation were 87.8%and 90.3%, respectively. T2 (hazard ratio [HR], 2.30; 95% confidence interval [CI], 1.08 to4.94) and anterior commissural involvement (HR, 3.37; 95% CI, 1.62 to 7.02) were significantprognostic factors for LRFS. In 34 patients with local recurrence, tumors recurred inthe ipsilateral vocal cord in 28 patients. There were no contralateral vocal cord recurrences.
Most acute complications included grade 1-2 dysphagia and/or hoarseness. There was nograde 3 or greater chronic toxicity.
ConclusionDefinitive RT achieved a high cure rate, voice preservation, and tolerable toxicity in earlyglottic cancer. T2 stage and anterior commissural involvement were prognostic factors forlocal control. Further optimization of the RT method is needed to reduce the risk of ipsilateraltumor recurrence.
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참고문헌 (23)
참고문헌 신청
American Society of Clinical Oncology / 2006 / American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatmen
Burke LS / 1997 / Definitive radiotherapy for early glottic carcinoma : prognostic factors and implications for treatment / Int J Radiat Oncol Biol Phys 38 : 1001 ~ 1006
Chera BS / 2010 / Carotidsparing intensity-modulated radiotherapy for early-stage squamous cell carcinoma of the true vocal cord / Int J Radiat Oncol Biol Phys 77 : 1380 ~ 1
Chera BS / 2010 / T1N0 to T2N0 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy / Int J Radiat Oncol Biol Phys 78 : 461 ~ 466
Fowler JF / 2003 / Acute radiation reactions in oral and pharyngeal mucosa : tolerable levels in altered fractionation schedules / Radiother Oncol 69 : 161 ~ 168
Burke LS / 1997 / Definitive radiotherapy for early glottic carcinoma : prognostic factors and implications for treatment / Int J Radiat Oncol Biol Phys 38 : 1001 ~ 1006
Chera BS / 2010 / Carotidsparing intensity-modulated radiotherapy for early-stage squamous cell carcinoma of the true vocal cord / Int J Radiat Oncol Biol Phys 77 : 1380 ~ 1
Chera BS / 2010 / T1N0 to T2N0 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy / Int J Radiat Oncol Biol Phys 78 : 461 ~ 466
Fowler JF / 2003 / Acute radiation reactions in oral and pharyngeal mucosa : tolerable levels in altered fractionation schedules / Radiother Oncol 69 : 161 ~ 168
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