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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 61 - 69 (9page)
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Purpose The aim of this study was to examine patterns of radiotherapy (RT) in Korean patients with hepatocellular carcinoma (HCC) according to the evolving guideline for HCC established by the Korean Liver Cancer Study Group-National Cancer Center (KLCSG-NCC).
Materials and Methods We reviewed 765 patients with HCC who were treated with RT between January 2011 and December 2012 in 12 institutions.
Results The median follow-up period was 13.3 months (range, 0.2 to 51.7 months). Compared with previous data between 2004 and 2005, the use of RT as a first treatment has increased (9.0% vs. 40.8%). Increased application of intensity-modulated RT resulted in an increase in radiation dose (fractional dose, 1.8 Gy vs. 2.5 Gy; biologically effective dose, 53.1 Gy10 vs. 56.3 Gy10). Median overall survival was 16.2 months, which is longer than that reported in previous data (12 months). In subgroup analysis, treatments were significantly different according to stage (p < 0.001). Stereotactic body RT was used in patients with early HCC, and most patients with advanced stage were treated with three-dimensional conformal RT.
Conclusion Based on the evolving KLCSG-NCC practice guideline for HCC, clinical practice patterns of RT have changed. Although RT is still used mainly in advanced HCC, the number of patients with good performance status who were treated with RT as a first treatment has increased.
This change in practice patterns could result in improvement in overall survival.
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참고문헌 (20)
참고문헌 신청
Cha H / 2013 / Clinical factors related to recurrence after hepatic arterial concurrent chemoradiotherapy for advanced but liver-confined hepatocellular carcinoma / J Radiat
Cha J / 2012 / Application of radiotherapeutic strategies in the BCLC-defined stages of hepatocellular carcinoma / Liver Cancer 1 : 216 ~ 225
Cho JY / 2014 / The feasibility of combined transcatheter arterial chemoembolization and radiotherapy for advanced hepatocellular carcinoma / Liver Int 34 : 795 ~ 801
Choi C / 2014 / A prospective phase 2 multicenter study for the efficacy of radiation therapy following incomplete transarterial chemoembolization in unresectable hepatocell
Choi Y / 2014 / Overall response of both intrahepatic tumor and portal vein tumor thrombosis is a good prognostic factor for hepatocellular carcinoma patients receiving conc
Cha J / 2012 / Application of radiotherapeutic strategies in the BCLC-defined stages of hepatocellular carcinoma / Liver Cancer 1 : 216 ~ 225
Cho JY / 2014 / The feasibility of combined transcatheter arterial chemoembolization and radiotherapy for advanced hepatocellular carcinoma / Liver Int 34 : 795 ~ 801
Choi C / 2014 / A prospective phase 2 multicenter study for the efficacy of radiation therapy following incomplete transarterial chemoembolization in unresectable hepatocell
Choi Y / 2014 / Overall response of both intrahepatic tumor and portal vein tumor thrombosis is a good prognostic factor for hepatocellular carcinoma patients receiving conc
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