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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 549 - 554 (6page)
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Advances in oncology research have led to identification of tumor-specific biomarkers, someof which are important predictive indicators and ideal targets for novel therapeutics. Onesuch biomarker in non-small cell lung cancer (NSCLC) is the epidermal growth factor receptor(EGFR). Patients with NSCLC who harbor an activating EGFR mutation show a morefavorable response to treatment with an EGFR inhibitor, such as gefitinib, erlotinib, or afatinib,than to chemotherapy. The prevalence of EGFR mutations in East Asian patients ishigher than that in other populations, and in some clinical settings, patients have beentreated with EGFR inhibitors based on clinicopathologic characteristics with no informationon EGFR status. However, based on results from a series of studies in which East Asianpatients with advanced non-squamous NSCLC were treated with EGFR inhibitors alone orin combination with standard chemotherapy, this may not be the best practice becauseEGFRmutation status was found to be a key predictor of outcome. Data from these studieshighlight the necessity of EGFR testing in determining the most suitable treatment forpatients with advanced or metastatic NSCLC.
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참고문헌 (18)
참고문헌 신청
Ahn MJ / 2012 / Randomized phase II trial o
Brega E / 2014 / Non-small cell lung carcinoma biomarker testing : the pathologist's perspective / Front Oncol 4 : 182 ~
Garassino MC / 2009 / Biological and clinical features in predicting efficacy of epidermal growth factor receptor tyrosine kinase inhibitors : a systematic review and meta-a
Lee DH / 2013 / Three-arm randomised controlled phase 2 study comparing pemetrexed and erlotinib to either pemetrexed or erlotinib alone as second-line treatment for never-s
Lindeman NI / 2013 / Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors : guideline from the College of American Pa
Brega E / 2014 / Non-small cell lung carcinoma biomarker testing : the pathologist's perspective / Front Oncol 4 : 182 ~
Garassino MC / 2009 / Biological and clinical features in predicting efficacy of epidermal growth factor receptor tyrosine kinase inhibitors : a systematic review and meta-a
Lee DH / 2013 / Three-arm randomised controlled phase 2 study comparing pemetrexed and erlotinib to either pemetrexed or erlotinib alone as second-line treatment for never-s
Lindeman NI / 2013 / Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors : guideline from the College of American Pa
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