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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제49권 제6호
- 발행연도
- 2015.1
- 수록면
- 481 - 488 (8page)
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초록· 키워드
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Background: Analysis of mutations in the epidermal growth factor receptor gene (EGFR) is important for predicting response to EGFR tyrosine kinase inhibitors. The overall rate of EGFR mutations in Korean patients is variable. To obtain comprehensive data on the status of EGFR mutations in Korean patients with lung cancer, the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists initiated a nationwide survey. Methods: We obtained 1,753 reports on EGFR mutations in patients with lung cancer from 15 hospitals between January and December 2009. We compared EGFR mutations with patient age, sex, history of smoking, histologic diagnosis, specimen type, procurement site, tumor cell dissection, and laboratory status. Results: The overall EGFR mutation rate was 34.3% in patients with non-small cell lung cancer (NSCLC) and 43.3% in patients with adenocarcinoma. EGFR mutation rate was significantly higher in women, never smokers, patients with adenocarcinoma, and patients who had undergone excisional biopsy. EGFR mutation rates did not differ with respect to patient age or procurement site among patients with NSCLC. Conclusions: EGFR mutation rates and statuses were similar to those in published data from other East Asian countries.
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참고문헌 (20)
참고문헌 신청
Ahn MJ / 2008 / Are there any ethnic differences in molecular predictors of erlotinib efficacy in advanced non-small cell lung cancer? / Clin Cancer Res 14 : 3860 ~ 3866
Bae NC / 2007 / EGFR, ERBB2, and KRAS mutations in Korean non-small cell lung cancer patients / Cancer Genet Cytogenet 173 : 107 ~ 113
Fukuoka M / 2011 / Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel
Gahr S / 2013 / EGFR mutational status in a large series of Caucasian European NSCLC patients : data from daily practice / Br J Cancer 109 : 1821 ~ 1828
Lee YJ / 2009 / Activating mutations within the EGFR kinase domain: a molecular predictor of disease-free survival in resected pulmonary adenocarcinoma / J Cancer Res Clin O
Bae NC / 2007 / EGFR, ERBB2, and KRAS mutations in Korean non-small cell lung cancer patients / Cancer Genet Cytogenet 173 : 107 ~ 113
Fukuoka M / 2011 / Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel
Gahr S / 2013 / EGFR mutational status in a large series of Caucasian European NSCLC patients : data from daily practice / Br J Cancer 109 : 1821 ~ 1828
Lee YJ / 2009 / Activating mutations within the EGFR kinase domain: a molecular predictor of disease-free survival in resected pulmonary adenocarcinoma / J Cancer Res Clin O
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