지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 171 - 176 (6page)
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초록· 키워드
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Purpose: Gallbladder cancer is a malignancy with poor prognosis, predominantly resulting from invasion and metastasis. Our previous studies have demonstrated that prostaglandin E2 (PGE2), generated by cyclooxygenase 2 (Cox-2), transactivates epidermal growth factor receptor(EGFR), c-Met and β-catenin; thus, enhancing colon cancer cell growth and invasiveness in vitro. To determine whether these findings are applicable to clinical conditions, we examined the expression and cellular localization/co-localization of Cox-2, c-Met, β-catenin, EGFR and c-erbB2 in gallbladder cancer.
Materials and Methods: Thirty-five specimens of invasive gallbladder cancer, 8 in situ carcinoma and 7 adenoma specimens were immunostained with specific antibodies against Cox-2, c-Met, β-catenin, EGFR and c-erbB2. The cellular distribution, localization and colocalization were examined, and the signal intensities quantified in: a) the central area of gallbladder cancer and b) cancer cells forming the invasive front.
Results: Cox-2, c-Met, β-catenin, c-erbB2 and EGFR were over-expressed in 80, 74, 71, 62 and 11% of invasive gallbladder cancers, respectively. β-catenin was expressed in 80% of non-malignant specimens, exclusively in the cell membrane, while the cancer specimens showed cytoplasmic and/or nuclear staining. Significantly higher Cox-2, c-Met and β-catenin expressions were present in cancer cells of the invasive front than in the tumor central areas (p＜0.001), and these expressions were significantly (p=0.01) associated with the invasion depth. Coexpressions of Cox-2, c-Met, β-catenin and c-erbB2 were present in 42% of the specimens in cancer cells forming the invasive front.
Conclusion: The overexpressions, and often co-localizations, of Cox-2, c-Met and β-catenin in cancer cells forming the invasive front indicate their local interactions and important roles in invasion. invasion.
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참고문헌 (24)
참고문헌 신청
/ 1984 / Molecular cloning of a new transforming gene froma chemically transformed human cell line 311 : 29 ~ 33
/ 1990 / Gallbladder cancer:the polyp-cancersequence 77 : 363 ~ 4
/ 1991 / WHO histologictyping of tumors of the gallbladder and extrahepatic bile ducts International Histologic Classification of Tumors
/ 1993 / An immunohistochemicaland molecular biological study of c-erbB-2 amplificationand prognostic relevance in gallbladder cancer 189 : 283 ~ 92
/ 1994 / Up-regulation of cyclooxygenase 2 gene expressionin human colorectal adenomas and adenocarcinomas 107 : 1183 ~ 8
/ 1990 / Gallbladder cancer:the polyp-cancersequence 77 : 363 ~ 4
/ 1991 / WHO histologictyping of tumors of the gallbladder and extrahepatic bile ducts International Histologic Classification of Tumors
/ 1993 / An immunohistochemicaland molecular biological study of c-erbB-2 amplificationand prognostic relevance in gallbladder cancer 189 : 283 ~ 92
/ 1994 / Up-regulation of cyclooxygenase 2 gene expressionin human colorectal adenomas and adenocarcinomas 107 : 1183 ~ 8
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