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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 274 - 281 (8page)
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초록· 키워드
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Purpose The purpose of this study was to evaluate the outcome of adjuvant chemoradiotherapy(CRT) after distal pancreatectomy (DP) in patients with pancreatic adenocarcinoma, and toidentify the prognostic factors for these patients.
Materials and MethodsWe performed a retrospective review of 62 consecutive patients who underwent curativeDP followed by adjuvant CRT between 2000 and 2011. There were 31 men and 31 women,and the median age was 64 years (range, 38 to 80 years). Adjuvant radiotherapy wasdelivered to the tumor bed and regional lymph nodes with a median dose of 50.4 Gy (range,40 to 55.8 Gy). All patients received concomitant chemotherapy, and 53 patients (85.5%)also received maintenance chemotherapy. The median follow-up period was 24 months.
ResultsForty patients (64.5%) experienced relapse. Isolated locoregional recurrence developed in5 patients (8.1%) and distant metastasis in 35 patients (56.5%), of whom 13 had bothlocoregional recurrence and distant metastasis. The median overall survival (OS) anddisease-free survival (DFS) were 37.5 months and 15.4 months, respectively. On multivariateanalysis, splenic artery (SA) invasion (p=0.0186) and resection margin (RM) involvement(p=0.0004) were identified as significant adverse prognosticators for DFS. Also, male gender(p=0.0325) and RM involvement (p=0.0007) were associated with a significantly poor OS.
Grade 3 or higher hematologic and gastrointestinal toxicities occurred in 22.6% and 4.8%of patients, respectively.
ConclusionAdjuvant CRT may improve survival after DP for pancreatic body or tail adenocarcinoma.
Our results indicated that SA invasion was a significant factor predicting inferior DFS, aswas RM involvement. When SA invasion is identified preoperatively, neoadjuvant treatmentmay be considered.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Brennan MF / 1996 / Management of adenocarcinoma of the body and tail of the pancreas / Ann Surg 223 : 506 ~ 511
Christein JD / 2005 / Distal pancreatectomy for resectable adenocarcinoma of the body and tail of the pancreas / J Gastrointest Surg 9 : 922 ~ 927
Corsini MM / 2008 / Adjuvant radiotherapy and chemotherapy for pancreatic carcinoma : the Mayo Clinic experience(1975-2005) / J Clin Oncol 26 : 3511 ~ 3516
Garcea G / 2008 / Survival following curative resection for pancreatic ductal adenocarcinoma. A systematic review of the literature / JOP 9 : 99 ~ 132
Hattangadi JA / 2009 / Results and patterns of failure in patients treated with adjuvant combined chemoradiation therapy for resected pancreatic adenocarcinoma / Cancer 115
Christein JD / 2005 / Distal pancreatectomy for resectable adenocarcinoma of the body and tail of the pancreas / J Gastrointest Surg 9 : 922 ~ 927
Corsini MM / 2008 / Adjuvant radiotherapy and chemotherapy for pancreatic carcinoma : the Mayo Clinic experience(1975-2005) / J Clin Oncol 26 : 3511 ~ 3516
Garcea G / 2008 / Survival following curative resection for pancreatic ductal adenocarcinoma. A systematic review of the literature / JOP 9 : 99 ~ 132
Hattangadi JA / 2009 / Results and patterns of failure in patients treated with adjuvant combined chemoradiation therapy for resected pancreatic adenocarcinoma / Cancer 115
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