지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 232 - 239 (8page)
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초록· 키워드
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Purpose The objective of this study was to explore the relationship between the circulating lympho- cyte level during preoperative chemoradiotherapy (CRT) and pathologic complete response (pCR) in locally advanced rectal cancer.
Materials and Methods From May 2010 to May 2013, 52 patients treated with preoperative CRT followed by surgery, were analysed. Patients received conventional fractionated radiotherapy (50-54 Gy) with fluorouracil-based chemotherapy. Surgical resection was performed at 4 to 8 weeks after the completion of preoperative CRT. Absolute blood lymphocyte counts and their rel- ative percentage in total white blood cell counts were obtained from complete blood count tests performed prior to and after 4, 8, and 12 weeks of CRT. We analysed the association between achieving pCR and change in blood lymphocyte level during CRT, as well as clinical parameters.
Results Among 52 patients, 14 (26.9%) had evidence of pCR. Sustaining the blood lymphocyte count during CRT (lymphocyte count at 4 weeks/baseline lymphocyte count > 0.35; odds ratio, 8.33; p=0.02) and initial carcinoembryonic antigen < 4.4 ng/mL (odds ratio, 6.71; p=0.03) were significantly associated with pCR in multivariate analyses.
Conclusion Sustaining blood lymphocyte count during preoperative CRT was predictive for pCR in rectal cancer. Further studies are warranted to investigate the association between pathologic responses and circulating lymphocyte count with its subpopulation during preoperative CRT.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Sauer R / 2004 / Preoperative versus postoperative chemoradiotherapy for rectal cancer / N Engl J Med 351:1731~1740
공문규 / 2012 / Preoperative Concurrent Chemoradiotherapy for Locally Advanced Rectal Cancer: Treatment Outcomes and Analysis of Prognostic Factors / Cancer Research and Treatment 44(2):104~112
Martin ST / 2012 / Systematic review and meta-analysis of outcomes following pathological complete response to neoadjuvant chemoradiotherapy for rectal cancer / Br J Surg 99:918~928
Maas M / 2010 / Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer : a pooled analysis of individual patient data / Lancet Oncol 11:835~844
Yeo SG / 2010 / Pathologic complete response of primary tumor following preoperative chemoradiotherapy for locally advanced rectal cancer : long-term outcomes and prognostic significance of pathologic nodal status(KROG 09-01) / Ann Surg 252:998~1004
공문규 / 2012 / Preoperative Concurrent Chemoradiotherapy for Locally Advanced Rectal Cancer: Treatment Outcomes and Analysis of Prognostic Factors / Cancer Research and Treatment 44(2):104~112
Martin ST / 2012 / Systematic review and meta-analysis of outcomes following pathological complete response to neoadjuvant chemoradiotherapy for rectal cancer / Br J Surg 99:918~928
Maas M / 2010 / Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer : a pooled analysis of individual patient data / Lancet Oncol 11:835~844
Yeo SG / 2010 / Pathologic complete response of primary tumor following preoperative chemoradiotherapy for locally advanced rectal cancer : long-term outcomes and prognostic significance of pathologic nodal status(KROG 09-01) / Ann Surg 252:998~1004
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