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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 942 - 947 (6page)
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초록· 키워드
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Purpose A telomerase reverse transcriptase (TERT) promoter mutation was identified in thyroid cancer.
This TERT promoter mutation is thought to be a prognostic molecular marker, because its association with tumor aggressiveness, persistence/recurrence, and disease-specific mortality in papillary thyroid carcinoma (PTC) has been reported. In this study, we attempted to determine whether the impact of the TERT promoter mutation on PTC persistence/ recurrence is independent of clinicopathological parameters.
Materials and Methods Using propensity score matching, 39 patients with PTC persistence or recurrence were matched with 35 patients without persistence or recurrence, with a similar age, sex, tumor size, multifocality, bilaterality, extrathyroidal extension, and lymph node metastasis. The TERT promoter and the BRAF V600E mutations were identified from PTC samples.
Results The TERT promoter mutation was detected in 18% of PTC patients (13/74). No significant difference in the frequency of the TERT promoter mutation was observed between the persistence/ recurrence group and the non-recurrence group.
Conclusion These results suggest that the prognostic implications of the TERT promoter mutation are dependent on clinicopathological parameters.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Smekalova EM / 2012 / Telomerase RNA biosynthesis and processing / Biochemistry(Mosc) 77:1120~1128
Kim NW / 1994 / Specific association of human telomerase activity with immortal cells and cancer / Science 266:2011~2015
Clark GM / 1997 / Telomerase activity and survival of patients with node-positive breast cancer / J Natl Cancer Inst 89:1874~1881
Huang FW / 2013 / Highly recurrent TERT promoter mutations in human melanoma / Science 339:957~959
Soares P / 2011 / Genetic alterations in poorly differentiated and undifferentiated thyroid carcinomas / Curr Genomics 12:609~617
Kim NW / 1994 / Specific association of human telomerase activity with immortal cells and cancer / Science 266:2011~2015
Clark GM / 1997 / Telomerase activity and survival of patients with node-positive breast cancer / J Natl Cancer Inst 89:1874~1881
Huang FW / 2013 / Highly recurrent TERT promoter mutations in human melanoma / Science 339:957~959
Soares P / 2011 / Genetic alterations in poorly differentiated and undifferentiated thyroid carcinomas / Curr Genomics 12:609~617
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