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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 252 - 262 (11page)
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초록· 키워드
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Recent advances in molecular diagnostics have led to significant insights into the genetic basis of thyroid tumorigenesis. Among the mutations commonly seen in thyroid cancers, the vast majority are associated with the mitogen-activated protein kinase pathway. B-Raf proto-oncogene (BRAF) mutations are the most common mutations observed in papillary thyroid cancers (PTCs), followed by RET/PTC rearrangements and RAS mutations, while follicular thyroid cancers are more likely to harbor RAS mutations or PAX8/peroxisome proliferator-activated receptor γ (PPARγ) rearrangements. Beyond these more common mutations, alterations in the telomerase reverse transcriptase (TERT) promoter have recently been associated with clinicopathologic features, disease prognosis, and tumorigenesis in thyroid cancer. While the mutations underlying thyroid tumorigenesis are well known, the frequency of these mutations is strongly associated with geography, with clear differences reported between Asian and Western countries. Of particular interest is the prevalence of BRAF mutations, with Korean patients exhibiting the highest rate of BRAF-associated thyroid cancers in the world. Here, we review the prevalence of each of the most common mutations in Asian and Western countries, and identify the characteristics of well-differentiated thyroid cancer in Asians.
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참고문헌 (97)
참고문헌 신청
Xing M / 2010 / Prognostic utility of BRAF mutation in papillary thyroid cancer / Mol Cell Endocrinol 321:86~93
Xing M / 2013 / Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer / JAMA 309:1493~1501
Ito Y / 2009 / BRAF mutation in papillary thyroid carcinoma in a Japanese population: its lack of correlation with high-risk clinicopathological features and disease-free survival of patients / Endocr J 56:89~97
Kim TY / 2005 / The BRAF mutation is not associated with poor prognostic factors in Korean patients with conventional papillary thyroid microcarcinoma / Clin Endocrinol (Oxf) 63:588~593
Goutas N / 2008 / BRAF and K-RAS mutation in a Greek papillary and medullary thyroid carcinoma cohort / Anticancer Res 28(1A):305~308
Xing M / 2013 / Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer / JAMA 309:1493~1501
Ito Y / 2009 / BRAF mutation in papillary thyroid carcinoma in a Japanese population: its lack of correlation with high-risk clinicopathological features and disease-free survival of patients / Endocr J 56:89~97
Kim TY / 2005 / The BRAF mutation is not associated with poor prognostic factors in Korean patients with conventional papillary thyroid microcarcinoma / Clin Endocrinol (Oxf) 63:588~593
Goutas N / 2008 / BRAF and K-RAS mutation in a Greek papillary and medullary thyroid carcinoma cohort / Anticancer Res 28(1A):305~308
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