지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,399 - 1,407 (9page)
이용수
초록· 키워드
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Purpose The purpose of this study is to investigate the clinical significance of tyrosine hydroxylase (TH) expression in peripheral blood (PB) at diagnosis in patients with neuroblastoma.
Materials and Methods TH mRNA expression in PB was measured by reverse transcription quantitative real-time polymerase chain reaction in 210 patients who were newly diagnosed with neuroblastoma from July 2005 to June 2015 and the clinical significance of THexpression in PB at diagnosis was evaluated.
Results TH expression was positive in 60 patients (28.6%). Fifty of 60 TH-positive patients had metastatic tumors and the remaining 10 had localized tumors. TH expression was associated with high-risk features (i.e., advanced stage, older age, unfavorable pathology, and MYCN amplification) at diagnosis. Among TH-positive patients, higher TH expression level was observed in high-risk patients than in low- or intermediate-risk patients (p=0.035).
The probability of 5-year progression-free survival (PFS) was lower in TH-positive patients than in TH-negative patients (63.8±6.9% vs. 94.7±2.1%, p < 0.001). In analysis confined to high-risk patients, the 5-year probability of PFS remained lower in TH-positive patients (55.7±8.2% vs. 89.6±5.8%, p < 0.001). Among TH-positive patients, a higher expression level of TH was associated with a worse outcome. In multivariate analyses, positive TH expression in PB at diagnosis was an independent poor prognostic factor for PFS.
Conclusion The treatment intensity should be tailored according to TH expression in PB at diagnosis.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Shimada H / 1999 / Terminology and morphologic criteria of neuroblastic tumors : recommendations by the International Neuroblastoma Pathology Committee / Cancer 86:349~363
Brossard J / 1996 / Neuroblastoma : an enigmatic disease / Br Med Bull 52:787~801
Fukuda M / 2001 / Disease outcome may be predicted by molecular detection of minimal residual disease in bone marrow in advanced neuroblastoma : a pilot study / J Pediatr Hematol Oncol 23:10~13
Grima B / 1987 / A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics / Nature 326:707~711
Naito H / 1991 / Detection of tyrosine hydroxylase mRNA and minimal neuroblastoma cells by the reverse transcriptionpolymerase chain reaction / Eur J Cancer 27:762~765
Brossard J / 1996 / Neuroblastoma : an enigmatic disease / Br Med Bull 52:787~801
Fukuda M / 2001 / Disease outcome may be predicted by molecular detection of minimal residual disease in bone marrow in advanced neuroblastoma : a pilot study / J Pediatr Hematol Oncol 23:10~13
Grima B / 1987 / A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics / Nature 326:707~711
Naito H / 1991 / Detection of tyrosine hydroxylase mRNA and minimal neuroblastoma cells by the reverse transcriptionpolymerase chain reaction / Eur J Cancer 27:762~765
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