지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.99 No.2
- 발행연도
- 2020.8
- 수록면
- 118 - 126 (9page)
이용수
초록· 키워드
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Purpose: This study was performed to establish and validate a nomogram for predicting the overall survival in children with neuroblastoma.
Methods: The latest clinical data of neuroblastoma in Surveillance, Epidemiology, and End Results (SEER) database was extracted from 2000 to 2016. The cases included were randomly divided into training and validation cohorts. The survival curves were drawn with a Kaplan-Meier estimator to investigate the influences of certain single factors on overall survival. Also, least absolute shrinkage and selection operator regression was applied to further select the prognostic variables for neuroblastoma. Additionally, receiver operating characteristic (ROC) curves and calibration curves were used to evaluate the accuracy of the nomogram.
Results: In total, 1,262 patients were collected and 8 independent prognostic factors were achieved, including patients’ age, sex, race, tumor grade, radiotherapy, chemotherapy, tumor site, and tumor size. Then we constructed a nomogram by using the data of the training cohort with 886 cases. Subsequently, the nomogram was validated internally and externally with 886 and 376 cases, respectively. The internal validation revealed that the area under the curves (AUC) of ROC curves of 1-, 3-, and 5-year overall survival were 0.69, 0.78, and 0.81, respectively. Accordingly, the external validation also showed that the AUC of 1-, 3-, and 5-year overall survival were all ≥0.69. Both methods of validation demonstrated that the predictive calibration curves were consistent with standard curves.
Conclusion: The nomogram possess the potential to be a new tool in predicting the survival rate of neuroblastoma patients.
Methods: The latest clinical data of neuroblastoma in Surveillance, Epidemiology, and End Results (SEER) database was extracted from 2000 to 2016. The cases included were randomly divided into training and validation cohorts. The survival curves were drawn with a Kaplan-Meier estimator to investigate the influences of certain single factors on overall survival. Also, least absolute shrinkage and selection operator regression was applied to further select the prognostic variables for neuroblastoma. Additionally, receiver operating characteristic (ROC) curves and calibration curves were used to evaluate the accuracy of the nomogram.
Results: In total, 1,262 patients were collected and 8 independent prognostic factors were achieved, including patients’ age, sex, race, tumor grade, radiotherapy, chemotherapy, tumor site, and tumor size. Then we constructed a nomogram by using the data of the training cohort with 886 cases. Subsequently, the nomogram was validated internally and externally with 886 and 376 cases, respectively. The internal validation revealed that the area under the curves (AUC) of ROC curves of 1-, 3-, and 5-year overall survival were 0.69, 0.78, and 0.81, respectively. Accordingly, the external validation also showed that the AUC of 1-, 3-, and 5-year overall survival were all ≥0.69. Both methods of validation demonstrated that the predictive calibration curves were consistent with standard curves.
Conclusion: The nomogram possess the potential to be a new tool in predicting the survival rate of neuroblastoma patients.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
Luz Jubierre / 2018 / Targeting of epigenetic regulators in neuroblastoma / Experimental and Molecular Medicine 50:1~12
Rickman DS / 2018 / The expanding world of N-MYC-driven tumors / Cancer Discov 8:150~163
Meena JP / 2019 / Neuroblastoma in a developing country : miles to go / Indian J Pediatr 86:403~405
Zareifar S / 2020 / Successful treatment of refractory metastatic neuroblastoma with panobinostat in combination with chemotherapy agents and iodine-131-meta-iodobenzylguanidine therapy / J Oncol Pharm Pract 26:481~486
Herd F / 2019 / A systematic review of re-induction chemotherapy for children with relapsed high-risk neuroblastoma / Eur J Cancer 111:50~58
Rickman DS / 2018 / The expanding world of N-MYC-driven tumors / Cancer Discov 8:150~163
Meena JP / 2019 / Neuroblastoma in a developing country : miles to go / Indian J Pediatr 86:403~405
Zareifar S / 2020 / Successful treatment of refractory metastatic neuroblastoma with panobinostat in combination with chemotherapy agents and iodine-131-meta-iodobenzylguanidine therapy / J Oncol Pharm Pract 26:481~486
Herd F / 2019 / A systematic review of re-induction chemotherapy for children with relapsed high-risk neuroblastoma / Eur J Cancer 111:50~58
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UCI(KEPA) : I410-ECN-0101-2020-514-001102146