지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,253 - 1,263 (11page)
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초록· 키워드
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Purpose This study focused on implementation of a prognostic scoring index based on clinico-laboratory parameters measured routinely on admission in metastatic pancreatic cancer patients.
Materials and Methods Records from 403 patients of metastatic disease were analyzed retrospectively. Continuous variables were dichotomized according to the normal range or the best cut-off values statistically determined by Contal and O’Quigley method, and then analyzed in association with prognosis—overall survival (OS), using Cox’s proportional hazard model. Scores were calculated by summing the rounded chi-square scores for the factors that emerged in the multivariate analysis.
Results Performance status, hemoglobin, leucocyte count, neutrophil-lymphocyte ratio, and carcinoembryonic antigen were independent factors for OS. When patients were divided into three risk groups according to these factors, median survival was 11.7, 6.2, and 1.3 months for the low, intermediate, and high-risk groups, respectively (p < 0.001). Palliative chemotherapy has a significant survival benefit for low and intermediate-risk patients (median OS; 12.5 months vs. 5.9 months, p < 0.001 and 8.0 months vs. 2.0 months, p < 0.001, respectively).
Conclusion We advocate the use of a multivariable approach with continuous variables for prognostic modeling. Our index is helpful in accurate patient risk stratification and may aid in treatment selection.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Ryan DP / 2014 / Pancreatic adenocarcinoma / N Engl J Med 371:2140~2141
Ni XG / 2005 / The clinical value of serum CEA, CA19-9, and CA242 in the diagnosis and prognosis of pancreatic cancer / Eur J Surg Oncol 31:164~169
Stocken DD / 2008 / Modelling prognostic factors in advanced pancreatic cancer / Br J Cancer 99:883~893
Yi JH / 2011 / A prognostic model to predict clinical outcomes with first-line gemcitabine-based chemotherapy in advanced pancreatic cancer / Oncology 80:175~180
Ciela B. / 2011 / Hematology in practice / F.A. Davis Company
Ni XG / 2005 / The clinical value of serum CEA, CA19-9, and CA242 in the diagnosis and prognosis of pancreatic cancer / Eur J Surg Oncol 31:164~169
Stocken DD / 2008 / Modelling prognostic factors in advanced pancreatic cancer / Br J Cancer 99:883~893
Yi JH / 2011 / A prognostic model to predict clinical outcomes with first-line gemcitabine-based chemotherapy in advanced pancreatic cancer / Oncology 80:175~180
Ciela B. / 2011 / Hematology in practice / F.A. Davis Company
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