Lung Cancer in Women, a Different Disease: Survival Differences by Sex in Turkey

Ulas, Arife; Tokluoglu, Saadet; Kos, Mehmet; Silay, Kamile; Akinci, Sema; Oksuzoglu, Berna; Alkis, Necati

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자료유형: 학술저널

저자정보: Ulas, Arife (Department of Medical Oncology, Ankara Ataturk Training and Research Hospital) Tokluoglu, Saadet (Ankara Oncology Teaching and Research Hospital) Kos, Mehmet (Department of Internal Medicine, Faculty of Medicine, Duzce University) Silay, Kamile (Department of Internal Medicine and Geriatrics, Faculty of Medicine, Yildirim Beyazit University) Akinci, Sema (Department of Hematology, Ankara Ataturk Training and Research Hospital) Oksuzoglu, Berna (Ankara Oncology Teaching and Research Hospital) Alkis, Necati (Ankara Oncology Teaching and Research Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제2호

발행연도: 2015.1

수록면: 815 - 822 (8page)

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Purpose: In this study, we aimed to evaluate the effects of sex-based non-small cell lung cancer (NSCLC) varieties on survival rates. Materials and Methods: A retrospective study was performed in patients with NSCLC who were diagnosed by histological methods between the years 2000 and 2010. A chi-square test was used to compare variables. Overall survival (OS) was estimated by the Kaplan-Meier method. Results: Of the 844 patients, 117 (13.9%) were women and 727 (86.1%) were men. Adenocarcinoma was more common in women than in men (p<0.0001). There were more women non-smokers than men (p<0.0001). There was no statistically significant difference in ECOG PS, weight loss>10%, stage, LDH, albumin and treatment between women and men. Women younger than 65 years (17.0 vs 12.0 months; p=0.03), who had adenocarcinoma histology (15.0 vs 10.0 months; p=0.006) and who had a hemoglobin level ${\geq}12g/dL$ (18.0 vs 12.0 months; p=0.01) were found to have a better median OS rate than men. Median OS rates were found to be 13.0 months in females and 12.0 months in males (p=0.14). Among metastatic patients, the median OS was 11.0 months in females and 8.0 months in males (p=0.005). Among stage IIIB and stage IV patients who had first line platinum-based chemotherapy, the median OS was 17.0 months in women and 11.0 months in men (p=0.002). The response rate of chemotherapy was higher in women than in men (p=0.03). Conclusions: In our study, we found that survival duration is longer and chemotherapy response is better in women with NSCLC who do not have anemia or comorbidities and who are mostly non-smokers with adenocarcinomas. Further studies regarding the causes of these differences may provide clarity on this subject.

#Non-small cell lung cancer #adenocarcinoma #sex differences #survival #Turkey

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Ulas, Arife

소속기관 Department of Oncology, Ataturk Research and Training Hospital, Faculty of Medicine, Yildirim Beyazi