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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 95 - 102 (8page)
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Purpose Data are limited on programmed death ligand 1 (PD-L1) expression in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). Materials and Methods We retrospectively evaluated the relationship between PD-L1 expression and recurrencefree survival (RFS) and overall survival in 319 patients with EGFR-mutant NSCLC who were treated at Samsung Medical Center from 2006 to 2014. Membranous PD-L1 expression on tumor cells was measured using the PD-L1 IHC 22C3 pharmDx antibody and reported as tumor proportion score (TPS). Kaplan-Meier methods, log-rank test, and Cox proportional hazards models were used for survival analysis. Results All patients had ! 1 EGFR mutation—54% in exon 19 and 39% in exon 21. Overall, 51% of patients had PD-L1–positive tumors. The prevalence of PD-L1 positivity was higher among patients with stages II-IV versus stage I disease (64% vs. 44%) and among patients with other EGFR mutations (75%) than with L858R mutation (39%) or exon 19 deletion (52%). PD-L1 positivity was associated with shorter RFS, with an adjusted hazard ratio of 1.52 (95% confidence interval [CI], 0.81 to 2.84; median, 18 months) for the PD-L1 TPS ! 50% group, 1.51 (95% CI, 1.02 to 2.21; median, 31 months) for the PD-L1 TPS 1%-49% group, and 1.51 (95% CI, 1.05 to 2.18) for the combined PD-L1–positive groups (TPS ! 1%) compared with the PD-L1–negative group (median, 35 months). Conclusion PD-L1 expression is associated with disease stage and type of EGFR mutation. PD-L1 positivity might be associated with worse RFS among patients with surgically treated EGFRmutant NSCLC.
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참고문헌 (30)
참고문헌 신청
D'Addario G / 2010 / Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up / Ann Oncol 21(Suppl 5):v116~v119
Shigematsu H / 2005 / Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers / J Natl Cancer Inst 97:339~346
Bronte G / 2010 / Driver mutations and differential sensitivity to targeted therapies: a new approach to the treatment of lung adenocarcinoma / Cancer Treat Rev 36(Suppl 3):S21~S29
Luo SY / 2013 / Oncogenic driver mutations in lung cancer / Transl Respir Med 1:6
Shi Y / 2014 / A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology (PIONEER) / J Thorac Oncol 9:154~162
Shigematsu H / 2005 / Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers / J Natl Cancer Inst 97:339~346
Bronte G / 2010 / Driver mutations and differential sensitivity to targeted therapies: a new approach to the treatment of lung adenocarcinoma / Cancer Treat Rev 36(Suppl 3):S21~S29
Luo SY / 2013 / Oncogenic driver mutations in lung cancer / Transl Respir Med 1:6
Shi Y / 2014 / A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology (PIONEER) / J Thorac Oncol 9:154~162
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