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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 791 - 800 (10page)
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Purpose Although chemotherapy is recommended by various guidelines for advanced biliary tract cancer (BTC), the evidence supporting its use over best supportive care (BSC) is limited. The aim of this study was to investigate the survival benefit of chemotherapy over that of BSC in advanced BTC patients. Materials and Methods Advanced BTC patients with a good performance status (Eastern Cooperative Oncology Group [ECOG] 0-2) were eligible for the study. Data were retrospectively collected from four tertiary cancer centers and analyzed using propensity score matching (PSM). Of the 604 patients enrolled, 206 received BSC and 398 received chemotherapy. PSM analysis was performed using the following variables: age, ECOG status, carcinoembryonic antigen (CEA) level, white blood cell level, albumin level, total bilirubin level, and aspartate aminotransferase level. The sample size of each group was 164 patients after PSM. Median survival was compared between the two groups by using the Kaplan-Meier method, and prognostic factors were investigated using Cox proportional regression analysis. Results In post-PSM analysis, the respective median survival for the chemotherapy and BSC groups was dependent on the following prognostic factors: total population, 12.0 months vs. 7.5 months (p=0.001); locally advanced disease, 16.7 months vs. 13.4 months (p=0.490); cancer antigen 19-9 100 IU/mL, 12.7 months vs. 10.6 months (p=0.330); and CEA 3.4 ng/mL, 17.1 months vs. 10.6 months (p=0.052). Conclusion Chemotherapy improved overall survival of patients with advanced BTC who had a good performance status. However, this survival benefit was not observed in BTC patients with locally advanced disease or with lower tumor marker. Individualized approach is needed for initiation of palliative chemotherapy in advanced BTC.
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참고문헌 (16)
참고문헌 신청
Huguier M / 2001 / Randomized trial of 5-fluorouracil, leucovorin and cisplatin in advanced pancreatic cancer / Hepatogastroenterology 48:875~878
Mallinson CN / 1980 / Chemotherapy in pancreatic cancer: results of a controlled, prospective, randomised, multicentre trial / Br Med J 281:1589~1591
Palmer KR / 1994 / Chemotherapy prolongs survival in inoperable pancreatic carcinoma / Br J Surg 81:882~885
Brieau B / 2015 / Second-line chemotherapy for advanced biliary tract cancer after failure of the gemcitabine-platinum combination: a large multicenter study by the Association des Gastro-Enterologues Oncologues / Cancer 121:3290~3297
Fornaro L / 2015 / Second-line chemotherapy in advanced biliary cancer progressed to first-line platinum-gemcitabine combination: a multicenter survey and pooled analysis with published data / J Exp Clin Cancer Res 34:156
Mallinson CN / 1980 / Chemotherapy in pancreatic cancer: results of a controlled, prospective, randomised, multicentre trial / Br Med J 281:1589~1591
Palmer KR / 1994 / Chemotherapy prolongs survival in inoperable pancreatic carcinoma / Br J Surg 81:882~885
Brieau B / 2015 / Second-line chemotherapy for advanced biliary tract cancer after failure of the gemcitabine-platinum combination: a large multicenter study by the Association des Gastro-Enterologues Oncologues / Cancer 121:3290~3297
Fornaro L / 2015 / Second-line chemotherapy in advanced biliary cancer progressed to first-line platinum-gemcitabine combination: a multicenter survey and pooled analysis with published data / J Exp Clin Cancer Res 34:156
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