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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 956 - 963 (8page)
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Purpose Although the use of xenograft models is increasing, few studies have compared the clinical features or outcomes of epithelial ovarian cancer (EOC) patients according to the tumorigenicity of engrafted specimens. The purpose of this study was to evaluate whether tumorigenicity was associated with the clinical features and outcomes of EOC patients. Materials and Methods Eighty-eight EOC patients who underwent primary or interval debulking surgery from June 2014 to December 2015 were included. Fresh tumor specimens were implanted subcutaneously on each flank of immunodeficient mice. Patient characteristics, progression-free survival (PFS), and germline mutation spectra were compared according to tumorigenicity. Results Xenografts were established successfully from 49 of 88 specimens. Tumorigenicity was associated with lymphovascular invasion and there was a propensity to engraft successfully with high-grade tumors. Tumors from patients who underwent non-optimal (residual disease 1 cm) primary or interval debulking surgery had a significantly greater propensity to achieve tumorigenicity than those who received optimal surgery. In addition, patients whose tumors became engrafted seemed to have a shorter PFS and more frequent germline mutations than patients whose tumors failed to engraft. Tumorigenicity was a significant factor for predicting PFS with advanced International Federation of Gynecology and Obstetrics stage and high-grade cancers. Conclusion Tumorigenicity in a xenograft model was a strong prognostic factor and was associated with more aggressive tumors in EOC patients. Xenograft models can be useful as a preclinical tool to predict prognosis and could be applied to further pharmacologic and genomic studies on personalized treatments.
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참고문헌 (22)
참고문헌 신청
Siegel RL / 2016 / Cancer statistics, 2016 / CA Cancer J Clin 66:7~30
Erriquez J / 2016 / Xenopatients show the need for precision medicine approach to chemotherapy in ovarian cancer / Oncotarget 7:26181~26191
Nemati F / 2010 / Establishment and characterization of a panel of human uveal melanoma xenografts derived from primary and/or metastatic tumors / Clin Cancer Res 16:2352~2362
Kim MP / 2009 / Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice / Nat Protoc 4:1670~1680
Rubio-Viqueira B / 2009 / Direct in vivo xenograft tumor model for predicting chemotherapeutic drug response in cancer patients / Clin Pharmacol Ther 85:217~221
Erriquez J / 2016 / Xenopatients show the need for precision medicine approach to chemotherapy in ovarian cancer / Oncotarget 7:26181~26191
Nemati F / 2010 / Establishment and characterization of a panel of human uveal melanoma xenografts derived from primary and/or metastatic tumors / Clin Cancer Res 16:2352~2362
Kim MP / 2009 / Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice / Nat Protoc 4:1670~1680
Rubio-Viqueira B / 2009 / Direct in vivo xenograft tumor model for predicting chemotherapeutic drug response in cancer patients / Clin Pharmacol Ther 85:217~221
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