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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 701 - 711 (11page)
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Purpose The measuring Epstein-Barr virus (EBV) DNA is an important predictor of nasopharyngeal carcinoma (NPC). This study evaluated the predictive value of pretreatment serum amyloid A (SAA) and C-reactive protein (CRP) comparing with EBV DNA in patients with NPC. Materials and Methods In an observational study of 419 non-metastatic NPC patients, we prospectively evaluated the prognostic effects of pretreatment SAA, CRP, and EBV DNA on survival. The primary endpoint was progress-free survival (PFS). Results The median level of SAA and CRP was 4.28 mg/L and 1.88 mg/L, respectively. For the high- SAA group (> 4.28 mg/L) versus the low-SAA ( 4.28 mg/L) group and the high-CRP group (> 1.88 mg/L) versus the low-CRP ( 1.88 mg/L) group, the 5-year PFS was 64.5% versus 73.1% (p=0.013) and 65.2% versus 73.3% (p=0.064), respectively. EBV DNA detection showed a superior predictive result, the 5-year PFS in the EBV DNA 1,500 copies/mL group was obviously different than the EBV DNA < 1,500 copies/mL group (62.2% versus 77.8%, p < 0.001). Multifactorial Cox regression analysis confirmed that in the PFS, the independent prognostic factors were including EBV DNA (hazard ratio [HR], 1.788; p=0.009), tumour stage (HR, 1.903; p=0.021), and node stage (HR, 1.498; p=0.049), but the SAA and CRP were not included in the independent prognostic factors. Conclusion The results of SAA and CRP had a certain relationship with the prognosis of NPC, and the prognosis of patients with high level of SAA and CRP were poor. However, the predictive ability of SAA and CRP was lower than that of EBV DNA.
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참고문헌 (28)
참고문헌 신청
Wee JT / 2010 / Is nasopharyngeal cancer really a "Cantonese cancer"? / Chin J Cancer 29:517~526
Blanchard P / 2015 / Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis / Lancet Oncol 16:645~655
Wei WI / 2005 / Nasopharyngeal carcinoma / Lancet 365:2041~2054
Ludwig JA / 2005 / Biomarkers in cancer staging, prognosis and treatment selection / Nat Rev Cancer 5:845~856
Lin JC / 2004 / Quantification of plasma Epstein-Barr virus DNA in patients with advanced nasopharyngeal carcinoma / N Engl J Med 350:2461~2470
Blanchard P / 2015 / Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis / Lancet Oncol 16:645~655
Wei WI / 2005 / Nasopharyngeal carcinoma / Lancet 365:2041~2054
Ludwig JA / 2005 / Biomarkers in cancer staging, prognosis and treatment selection / Nat Rev Cancer 5:845~856
Lin JC / 2004 / Quantification of plasma Epstein-Barr virus DNA in patients with advanced nasopharyngeal carcinoma / N Engl J Med 350:2461~2470
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